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Tbio
BATF2
Basic leucine zipper transcriptional factor ATF-like 2

Protein Summary
Description
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301887
  • ENSP00000301887
  • ENSG00000168062
  • ENST00000435842
  • ENSP00000398911

Symbol
  • SARI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.63
biological process
0.58
tissue sample
0.56
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.24   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.24   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.888
Data Source:  STRINGDB
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
Score:  0.739
Data Source:  STRINGDB
MAGEB18
Tdark
Novelty:  0.90051976
Score:  0.737
Data Source:  STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
Score:  0.653
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.653
Data Source:  STRINGDB
NABP1
Tbio
Novelty:  0.09485689
Score:  0.603
Data Source:  STRINGDB
LYPD1
Tbio
Novelty:  0.10740408
Score:  0.597
Data Source:  STRINGDB
NDNF
Tbio
Novelty:  0.04171864
Score:  0.584
Data Source:  STRINGDB
TIGD5
Tdark
Novelty:  1.93340494
Score:  0.559
Data Source:  STRINGDB
EPAS1
Tchem
Novelty:  0.00307448
Score:  0.535
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
75.7
uric acid measurement
1
1
1
69
high density lipoprotein cholesterol measurement
1
1
1
48.5
1
1
0
1.9
13.9
metabolic syndrome
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
75.7
uric acid measurement
1
69
high density lipoprotein cholesterol measurement
1
48.5
0
1.9
13.9
metabolic syndrome
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper ATF-like transcription factor 2
VGNC:10236
451306
Macaque
basic leucine zipper ATF-like transcription factor 2
722022
Mouse
MGI:1921731
74481
Rat
RGD:1311481
309178
Dog
basic leucine zipper ATF-like transcription factor 2
VGNC:38386
483754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper ATF-like transcription factor 2
Macaque
basic leucine zipper ATF-like transcription factor 2
Mouse
Rat
Dog
basic leucine zipper ATF-like transcription factor 2
Publication Statistics
PubMed Score 31.24
PubMed score by year
PubTator Score 49.78
PubTator score by year
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Related Publications
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PMID
Year
Title