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Tbio
THEMIS
Protein THEMIS

Protein Summary
Description
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368248
  • ENSP00000357231
  • ENSG00000172673
  • ENST00000368250
  • ENSP00000357233
  • ENST00000537166
  • ENSP00000439863
  • ENST00000610842
  • ENSP00000480630
  • ENSG00000275122
  • ENST00000613862
  • ENSP00000480967
  • ENST00000614155
  • ENSP00000484170
  • ENST00000630369
  • ENSP00000487358

Symbol
  • C6orf190
  • C6orf207
  • GASP
  • SPOT
  • TSEPA
  • C6orf190
  • C6orf207
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.65
tissue sample
0.58
microRNA
0.56
cellular component
0.53
cell line
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.2
73.4
3
2
0
1.1
47.8
1
1
1
29.4
1
1
0
1.2
19.3
1
1
0
1.1
5.4
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
73.4
0
1.1
47.8
1
29.4
0
1.2
19.3
0
1.1
5.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443552
210757
Dog
thymocyte selection associated
VGNC:47343
484120
Horse
thymocyte selection associated
VGNC:24077
100073059
Cow
thymocyte selection associated
VGNC:35835
540554
Opossum
thymocyte selection associated
100030867
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
thymocyte selection associated
Horse
thymocyte selection associated
Cow
thymocyte selection associated
Opossum
thymocyte selection associated
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N1K5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (49)
1 – 10 of 49
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
p_int: 0.9392965
p_ni: 0.06070244
p_wrong: 0.00000106
Score: 0.775
Data Source: BioPlex,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.913233132
p_ni: 0.086766868
Score: 0.953
Data Source: BioPlex,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.784288881
p_ni: 0.215711119
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
LAT
Tbio
Novelty: 0.00738419
Score: 0.897
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.857
Data Source: STRINGDB
TESPA1
Tbio
Novelty: 0.12779533
Score: 0.841
Data Source: STRINGDB
DPT
Tbio
Novelty: 0.01984221
Score: 0.747
Data Source: STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.738
Data Source: STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.735
Data Source: STRINGDB
COPS4
Tbio
Novelty: 0.04672417
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.29

PubMed score by year
PubTator Score  28.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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