Tbio THEMIS Protein THEMIS

Protein Summary

Description

Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q8N1K5
• A1L4F0
• A8K7N1
• B3KT31
• B3KW32
• B3KY07
• F5H1J9
• Q5T3C4
• Q5T3C5
• Q6MZT7

Gene Name

• THEMIS

Ensembl ID

• ENST00000368248
• ENSP00000357231
• ENSG00000172673
• ENST00000368250
• ENSP00000357233
• ENST00000537166
• ENSP00000439863
• ENST00000610842
• ENSP00000480630
• ENSG00000275122
• ENST00000613862
• ENSP00000480967
• ENST00000614155
• ENSP00000484170
• ENST00000630369
• ENSP00000487358

Symbol

• C6orf190
• C6orf207
• GASP
• SPOT
• TSEPA
• C6orf190
• C6orf207

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.65
tissue sample	0.58
microRNA	0.56
cellular component	0.53
cell line	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0