You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CMTR1
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373451
  • ENSP00000362550
  • ENSG00000137200

Symbol
  • FTSJD2
  • KIAA0082
  • MTR1
  • MTr1
  • hMTr1
  • FTSJD2
  • KIAA0082
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.82
cell type or tissue
0.78
histone modification site profile
0.77
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0