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Tbio
NUP93
Nuclear pore complex protein Nup93

Protein Classes
Protein Summary
Description
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308159
  • ENSP00000310668
  • ENSG00000102900
  • ENST00000542526
  • ENSP00000440235
  • ENST00000564887
  • ENSP00000458039

Symbol
  • KIAA0095
  • NIC96
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
drug perturbation
0.99
pathway
0.99
kinase perturbation
0.91
histone modification site profile
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.09   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.09   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
30
35
99.9
apolipoprotein A 1 measurement
2
17
17
99.7
sleep duration
2
6
7
97.2
fish oil supplement exposure measurement
1
1
1
66.8
potassium measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
35
99.9
apolipoprotein A 1 measurement
17
99.7
sleep duration
7
97.2
fish oil supplement exposure measurement
1
66.8
potassium measurement
1
44.2
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 93
VGNC:5859
454107
Macaque
nucleoporin 93
710084
Mouse
MGI:1919055
71805
Rat
RGD:1311525
291874
Dog
nucleoporin 93
VGNC:44062
478119
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 93
Macaque
nucleoporin 93
Mouse
Rat
Dog
nucleoporin 93
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N1F7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (194)
1 – 10 of 194
NUP155
Tbio
Novelty:  0.03884486
Score:  0.999
Data Source:  Reactome,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
Score:  0.999
Data Source:  STRINGDB
NUP54
Tbio
Novelty:  0.08155008
Score:  0.999
Data Source:  STRINGDB
NUP188
Tbio
Novelty:  0.0698477
Score:  0.999
Data Source:  STRINGDB
NUP205
Tbio
Novelty:  0.06778513
Score:  0.999
Data Source:  Reactome,STRINGDB
NUP35
Tbio
Novelty:  0.0355102
Score:  0.998
Data Source:  Reactome,STRINGDB
NUP107
Tbio
Novelty:  0.01994155
Score:  0.997
Data Source:  STRINGDB
NUP153
Tbio
Novelty:  0.00696568
Score:  0.996
Data Source:  STRINGDB
NUP133
Tbio
Novelty:  0.02115225
Score:  0.991
Data Source:  STRINGDB
RAE1
Tbio
Novelty:  0.01342883
Score:  0.991
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.09

PubMed score by year
PubTator Score  11.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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