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Tbio
VPS52
Vacuolar protein sorting-associated protein 52 homolog

Protein Summary
Description
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383210
  • ENSP00000372697
  • ENSG00000206286
  • ENST00000428608
  • ENSP00000406988
  • ENSG00000236014
  • ENST00000441058
  • ENSP00000390831
  • ENSG00000228425
  • ENST00000443860
  • ENSP00000404016
  • ENSG00000224455
  • ENST00000445902
  • ENSP00000409952
  • ENSG00000223501
  • ENST00000448042
  • ENSP00000391197
  • ENSG00000225590

Symbol
  • SACM2L
  • ARE1
  • SAC2
  • SACM2L
  • dJ1033B10.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
co-expressed gene
0.87
transcription factor perturbation
0.8
kinase perturbation
0.71
cell line
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.83   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.83   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (171)
1 – 10 of 171
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.999999608
p_ni:  3.92e-7
Data Source:  BioPlex
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.999991699
p_ni:  0.000008301
Data Source:  BioPlex
EIPR1
Tbio
Novelty:  0.08803081
p_int:  0.999989719
p_ni:  0.000010281
Score:  0.747
Data Source:  BioPlex,STRINGDB
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999989338
p_ni:  0.000010662
Score:  0.621
Data Source:  BioPlex,STRINGDB
VPS50
Tbio
Novelty:  0.17236696
p_int:  0.99998195
p_ni:  0.00001805
Score:  0.997
Data Source:  BioPlex,STRINGDB
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
p_int:  0.999876054
p_ni:  0.000123946
Data Source:  BioPlex
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.999824955
p_ni:  0.000175045
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.999114436
p_ni:  0.000885564
Data Source:  BioPlex
ENOPH1
Tbio
Family:  Enzyme
Novelty:  0.07679925
p_int:  0.997358269
p_ni:  0.002641731
Score:  0.244
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.994481583
p_ni:  0.005518417
Data Source:  BioPlex
Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (60)
Items per page:
1 – 5 of 60
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
Items per page:
1 – 5 of 60
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
VPS52, GARP complex subunit
100430905
Mouse
MGI:1330304
224705
Rat
RGD:3618
25218
Dog
VPS52, GARP complex subunit
VGNC:48296
474871
Horse
VPS52, GARP complex subunit
VGNC:24935
100052599
Species
Name
OMA
EggNOG
Inparanoid
Macaque
VPS52, GARP complex subunit
Mouse
Rat
Dog
VPS52, GARP complex subunit
Horse
VPS52, GARP complex subunit
Publication Statistics
PubMed Score 62.83
PubMed score by year
PubTator Score 689.74
PubTator score by year