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Tbio
VPS52
Vacuolar protein sorting-associated protein 52 homolog

Protein Summary
Description
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383210
  • ENSP00000372697
  • ENSG00000206286
  • ENST00000428608
  • ENSP00000406988
  • ENSG00000236014
  • ENST00000441058
  • ENSP00000390831
  • ENSG00000228425
  • ENST00000443860
  • ENSP00000404016
  • ENSG00000224455
  • ENST00000445902
  • ENSP00000409952
  • ENSG00000223501
  • ENST00000448042
  • ENSP00000391197
  • ENSG00000225590

Symbol
  • SACM2L
  • ARE1
  • SAC2
  • SACM2L
  • dJ1033B10.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
co-expressed gene
0.87
transcription factor perturbation
0.8
kinase perturbation
0.71
cell line
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.52   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.52   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0