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Tbio
CCAR2
Cell cycle and apoptosis regulator protein 2

Protein Summary
Description
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308511
  • ENSP00000310670
  • ENSG00000158941
  • ENST00000389279
  • ENSP00000373930

Symbol
  • DBC1
  • KIAA1967
  • DBC1
  • DBC-1
  • NET35
  • p30DBC
  • p30 DBC
  • KIAA1967
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
biological process
0.89
cellular component
0.73
transcription factor binding site profile
0.69
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.99   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.99   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
p_int:  0.999998552
p_ni:  0.000001448
Score:  0.842
Data Source:  BioPlex,STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
p_int:  0.999043987
p_ni:  0.000956013
Score:  0.692
Data Source:  BioPlex,STRINGDB
MCC
Tbio
Novelty:  0.10374312
p_int:  0.981683907
p_ni:  0.016855828
p_wrong:  0.001460266
Score:  0.28
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.969019275
p_ni:  0.030980725
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.94338937
p_ni:  0.05661063
Score:  0.98
Data Source:  BioPlex,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.934974378
p_ni:  0.065025622
Score:  0.213
Data Source:  BioPlex,STRINGDB
TUBA1A
Tchem
Novelty:  0.01030145
p_int:  0.899757117
p_ni:  0.100242883
Score:  0.173
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.858114252
p_ni:  0.141885746
p_wrong:  2e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.988
Data Source:  Reactome,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.965
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
74.5
platelet count
1
1
1
73.9
platelet crit
1
1
1
73
glomerular filtration rate
2
2
2
70.4
creatinine measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
74.5
platelet count
1
73.9
platelet crit
1
73
glomerular filtration rate
2
70.4
creatinine measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cell cycle and apoptosis regulator 2
716288
Mouse
MGI:2444228
219158
Dog
cell cycle and apoptosis regulator 2
VGNC:38774
486122
Horse
cell cycle and apoptosis regulator 2
VGNC:16105
100057554
Pig
cell cycle and apoptosis regulator 2
100155718
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cell cycle and apoptosis regulator 2
Mouse
Dog
cell cycle and apoptosis regulator 2
Horse
cell cycle and apoptosis regulator 2
Pig
cell cycle and apoptosis regulator 2
Publication Statistics
PubMed Score 23.99
PubMed score by year
PubTator Score 54.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title