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Tbio
NAGS
N-acetylglutamate synthase, mitochondrial

Protein Summary
Description
Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293404
  • ENSP00000293404
  • ENSG00000161653

Symbol
  • AGAS
  • ARGA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.69
tissue sample
0.69
PubMedID
0.62
cellular component
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.06   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.06   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
96.8
triglyceride measurement
2
2
2
69.7
sex hormone-binding globulin measurement
4
2
4
55.2
urate measurement
1
1
1
53.7
bone density
1
2
2
40.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
96.8
triglyceride measurement
2
69.7
sex hormone-binding globulin measurement
4
55.2
urate measurement
1
53.7
bone density
2
40.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetylglutamate synthase
VGNC:9469
468274
Macaque
N-acetylglutamate synthase
714102
Mouse
MGI:2387600
217214
Rat
RGD:1565783
303563
Dog
N-acetylglutamate synthase
VGNC:43611
490943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetylglutamate synthase
Macaque
N-acetylglutamate synthase
Mouse
Rat
Dog
N-acetylglutamate synthase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N159-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Urea cycle
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Urea cycle
Protein-Protein Interactions (93)
1 – 10 of 93
OTC
Tchem
Family:  Enzyme
Novelty:  0.00544004
Score:  0.99
Data Source:  STRINGDB
ASS1
Tbio
Family:  Enzyme
Novelty:  0.00358761
Score:  0.987
Data Source:  STRINGDB
ASL
Tbio
Family:  Enzyme
Novelty:  0.00624709
Score:  0.962
Data Source:  STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
Score:  0.935
Data Source:  STRINGDB
CPS1
Tclin
Family:  Enzyme
Novelty:  0.00917469
Score:  0.929
Data Source:  STRINGDB
GLUD2
Tbio
Family:  Enzyme
Novelty:  0.01470266
Score:  0.925
Data Source:  STRINGDB
GPT2
Tbio
Family:  Enzyme
Novelty:  0.00478585
Score:  0.919
Data Source:  STRINGDB
GPT
Tbio
Family:  Enzyme
Novelty:  0.00003498
Score:  0.919
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.907
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.903
Data Source:  STRINGDB
Publication Statistics
PubMed Score  213.06

PubMed score by year
PubTator Score  76.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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