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Tbio
GPC2
Glypican-2

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292377
  • ENSP00000292377
  • ENSG00000213420
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
gene perturbation
0.74
pathway
0.69
cellular component
0.63
biological process
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.14   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.14   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.999973997
p_ni:  3.43e-7
p_wrong:  0.000025659
Data Source:  BioPlex
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.977
Data Source:  STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.976
Data Source:  STRINGDB
EXT1
Tbio
Family:  Enzyme
Novelty:  0.00355951
Score:  0.969
Data Source:  STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.968
Data Source:  STRINGDB
SDC3
Tbio
Novelty:  0.01095269
Score:  0.967
Data Source:  STRINGDB
AGRN
Tbio
Novelty:  0.00156441
Score:  0.967
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.962
Data Source:  STRINGDB
GLCE
Tbio
Family:  Enzyme
Novelty:  0.0497423
Score:  0.961
Data Source:  STRINGDB
NDST1
Tbio
Family:  Enzyme
Novelty:  0.00955868
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Reactome
Defective B4GALT7 causes EDS, progeroid type
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Defective B4GALT7 causes EDS, progeroid type
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
FEV/FEC ratio
1
1
1
62.5
ticagrelor measurement
1
1
1
36.5
dehydroepiandrosterone sulphate measurement
1
1
1
21.5
family history of Alzheimer’s disease
1
1
0
5.5
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
FEV/FEC ratio
1
62.5
ticagrelor measurement
1
36.5
dehydroepiandrosterone sulphate measurement
1
21.5
family history of Alzheimer’s disease
0
5.5
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glypican 2
VGNC:4377
472461
Mouse
MGI:1919201
71951
Rat
RGD:621363
171517
Dog
glypican 2
VGNC:41372
608542
Horse
glypican 2
VGNC:51138
100146435
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glypican 2
Mouse
Rat
Dog
glypican 2
Horse
glypican 2
Publication Statistics
PubMed Score 38.14
PubMed score by year
PubTator Score 8.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title