Tbio GPC2 Glypican-2

Protein Summary

Description

Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).

Uniprot Accession IDs

• Q8N158
• A4D2A7

Gene Name

• GPC2

Ensembl ID

• ENST00000292377
• ENSP00000292377
• ENSG00000213420

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.79
gene perturbation	0.74
pathway	0.69
cellular component	0.63
biological process	0.54

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.54   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.54   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glypican 2	VGNC:4377	472461
Mouse	glypican 2 (cerebroglycan)	MGI:1919201	71951
Rat	glypican 2	RGD:621363	171517
Dog	glypican 2	VGNC:41372	608542
Horse	glypican 2	VGNC:51138	100146435

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glypican 2
Mouse	glypican 2 (cerebroglycan)
Rat	glypican 2
Dog	glypican 2
Horse	glypican 2

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8N158-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)

Reactome (24)

PathwayCommons (2)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 24

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332
Reactome	Defective B3GAT3 causes JDSSDHD	20 targets	R-HSA-3560801
Reactome	Defective B4GALT7 causes EDS, progeroid type	20 targets	R-HSA-3560783

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332
Defective B3GAT3 causes JDSSDHD	20 targets	R-HSA-3560801
Defective B4GALT7 causes EDS, progeroid type	20 targets	R-HSA-3560783

Gene Ontology Terms (13)

Components (7)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
endoplasmic reticulum	Inferred from Direct Assay (IDA)	LIFEdb
Golgi lumen	Traceable Author Statement (TAS)	Reactome
lysosomal lumen	Traceable Author Statement (TAS)	Reactome
plasma membrane	Traceable Author Statement (TAS)	Reactome
anchored component of plasma membrane	Inferred from Electronic Annotation (IEA)	InterPro
collagen-containing extracellular matrix	Inferred from Electronic Annotation (IEA)	InterPro
extracellular space	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

HADHA

Tbio

Novelty: 0.00385746

p_int: 0.999973997

p_ni: 3.43e-7

p_wrong: 0.000025659

Data Source: BioPlex

HSPG2

Tbio

Family: Enzyme

Novelty: 0.00159541

Score: 0.977

Data Source: STRINGDB

SDC2

Tbio

Novelty: 0.00597758

Score: 0.976

Data Source: STRINGDB

EXT1

Tbio

Family: Enzyme

Novelty: 0.00355951

Score: 0.969

Data Source: STRINGDB

SDC1

Tbio

Novelty: 0.00044792

Score: 0.968

Data Source: STRINGDB

SDC3

Tbio

Novelty: 0.01095269

Score: 0.967

Data Source: STRINGDB

AGRN

Tbio

Novelty: 0.00156441

Score: 0.967

Data Source: STRINGDB

SDC4

Tbio

Novelty: 0.00319073

Score: 0.962

Data Source: STRINGDB

GLCE

Tbio

Family: Enzyme

Novelty: 0.0497423

Score: 0.961

Data Source: STRINGDB

NDST1

Tbio

Family: Enzyme

Novelty: 0.00955868

Score: 0.958

Data Source: STRINGDB

Publication Statistics

PubMed Score  34.54

PubMed score by year

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PubTator Score  8.11

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Glycoprotein
GPI-anchor
Heparan sulfate
Lipoprotein
Membrane
Polymorphism
Proteoglycan
Reference proteome

MGI Phenotype Find Similar Targets

endocrine/exocrine gland phenotype
mortality/aging
renal/urinary system phenotype