Protein Summary
Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).
- ENST00000292377
- ENSP00000292377
- ENSG00000213420
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.79 | ||
gene perturbation | 0.74 | ||
pathway | 0.69 | ||
cellular component | 0.63 | ||
biological process | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.14 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.14 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (92)
HADHA
Novelty: 0.00385746
p_int: 0.999973997
p_ni: 3.43e-7
p_wrong: 0.000025659
Data Source: BioPlex
Nearest Tclin Targets
Pathways (26)
Reactome (24)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Reactome | Defective B3GAT3 causes JDSSDHD | ||||
Reactome | Defective B4GALT7 causes EDS, progeroid type | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Defective B3GAT3 causes JDSSDHD | ||||
Defective B4GALT7 causes EDS, progeroid type | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Components (7)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | LIFEdb | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hematocrit | 1 | 1 | 1 | 78.3 | |||||
FEV/FEC ratio | 1 | 1 | 1 | 62.5 | |||||
ticagrelor measurement | 1 | 1 | 1 | 36.5 | |||||
dehydroepiandrosterone sulphate measurement | 1 | 1 | 1 | 21.5 | |||||
family history of Alzheimer’s disease | 1 | 1 | 0 | 5.5 | 17.8 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hematocrit | 1 | 78.3 | |||||
FEV/FEC ratio | 1 | 62.5 | |||||
ticagrelor measurement | 1 | 36.5 | |||||
dehydroepiandrosterone sulphate measurement | 1 | 21.5 | |||||
family history of Alzheimer’s disease | 0 | 5.5 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glypican 2 | VGNC:4377 | 472461 | |||||
Mouse | MGI:1919201 | 71951 | ||||||
Rat | RGD:621363 | 171517 | ||||||
Dog | glypican 2 | VGNC:41372 | 608542 | |||||
Horse | glypican 2 | VGNC:51138 | 100146435 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glypican 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glypican 2 | |||||
Horse | glypican 2 | |||||
Publication Statistics
PubMed Score 38.14
PubMed score by year
PubTator Score 8.11
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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