Tbio LILRA2 Leukocyte immunoglobulin-like receptor subfamily A member 2

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 2

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 2

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 2

Protein / ... / Protease Inhibitor / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 2

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 2

Protein Summary

Description

Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q8N149
• O75020

Gene Name

• LILRA2

Ensembl ID

• ENST00000251376
• ENSP00000251376
• ENSG00000239998
• ENST00000251377
• ENSP00000251377
• ENST00000391738
• ENSP00000375618
• ENST00000611940
• ENSP00000478981
• ENSG00000275290
• ENST00000613573
• ENSP00000479743
• ENST00000616629
• ENSP00000481338
• ENST00000617409
• ENSP00000479914
• ENSG00000274000
• ENST00000620279
• ENSP00000480939
• ENST00000621721
• ENSP00000484762
• ENSG00000278634
• ENST00000622640
• ENSP00000483906

Symbol

• ILT1
• LIR7
• ILT1
• LIR7
• CD85H
• LIR-7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.67
kinase perturbation	0.66
cell type or tissue	0.58
protein domain	0.58
tissue	0.58

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 308   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (5)

Reactome (3)

KEGG (2)

Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Immune System	2246 targets	R-HSA-168256
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933

Gene Ontology Terms (21)

Functions (3)

Components (2)

Processes (16)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
IgM binding	Inferred from Direct Assay (IDA)	UniProtKB
antigen binding	Traceable Author Statement (TAS)	ProtInc
signaling receptor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (95)

Explore Interacting Targets

1 – 10 of 95

• See Interactions on String-DB

HLA-G

Tbio

Novelty: 0.00082058

Score: 0.938

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

HLA-C

Tbio

Novelty: 0.01022087

Score: 0.925

Data Source: STRINGDB

Publication Statistics

PubMed Score  10.91

PubMed score by year

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PubTator Score  12.9

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHLYRENKSASWV

1-70

RRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVVTGAYSKPTLSALPSPVVTLGGNVT

70-140

LQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPS

140-210

DLLELLVPGVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANF

210-280

TLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQF

280-350

HTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLPSDPLELVVSEA

350-420

AETLSPSQNKTDSTTTSLGQHPQDYTVENLIRMGVAGLVLVVLGILLFEAQHSQRSLQDAAGR

420-483

MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHLYRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVVTGAYSKPTLSALPSPVVTLGGNVTLQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVPGVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANFTLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQFHTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLPSDPLELVVSEAAETLSPSQNKTDSTTTSLGQHPQDYTVENLIRMGVAGLVLVVLGILLFEAQHSQRSLQDAAGR

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Innate immunity
Membrane