You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADSSL1
Adenylosuccinate synthetase isozyme 1

Protein Classes
Protein Summary
Description
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330877
  • ENSP00000331260
  • ENSG00000185100
  • ENST00000332972
  • ENSP00000333019

Symbol
  • ADSS1
  • MPD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
histone modification site profile
0.74
transcription factor perturbation
0.74
biological process
0.72
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.54   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.54   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
4
4
96.8
high density lipoprotein cholesterol measurement
8
6
10
96.5
sex hormone-binding globulin measurement
6
2
6
84.4
neutrophil count
1
1
1
27.3
vitamin C measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
4
96.8
high density lipoprotein cholesterol measurement
10
96.5
sex hormone-binding globulin measurement
6
84.4
neutrophil count
1
27.3
vitamin C measurement
1
24.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylosuccinate synthase like 1
VGNC:3506
467568
Macaque
adenylosuccinate synthase like 1
706585
Mouse
MGI:87947
11565
Rat
RGD:1590342
684425
Dog
adenylosuccinate synthase like 1
VGNC:50440
612692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylosuccinate synthase like 1
Macaque
adenylosuccinate synthase like 1
Mouse
Rat
Dog
adenylosuccinate synthase like 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N142-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (104)
1 – 10 of 104
ADSS
Tchem
Family:  Enzyme
Novelty:  0.0126472
p_int:  0.999996356
p_ni:  0.000003644
p_wrong:  1e-9
Score:  0.94
Data Source:  BioPlex,STRINGDB
YY1
Tbio
Family:  TF
Novelty:  0.00120891
p_int:  0.999903392
p_ni:  0.000096603
p_wrong:  6e-9
Data Source:  BioPlex
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.991
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.98
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.976
Data Source:  STRINGDB
AMPD1
Tchem
Family:  Enzyme
Novelty:  0.00486439
Score:  0.968
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.966
Data Source:  STRINGDB
GMPR2
Tbio
Family:  Enzyme
Novelty:  0.16707153
Score:  0.962
Data Source:  STRINGDB
GMPR
Tbio
Family:  Enzyme
Novelty:  0.03505649
Score:  0.958
Data Source:  STRINGDB
IMPDH2
Tclin
Family:  Enzyme
Novelty:  0.00815361
Score:  0.957
Data Source:  STRINGDB
Publication Statistics
PubMed Score  23.54

PubMed score by year
PubTator Score  6.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: