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Tbio
ABCA6
ATP-binding cassette sub-family A member 6

Protein Summary
Description
Probable transporter which may play a role in macrophage lipid homeostasis. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284425
  • ENSP00000284425
  • ENSG00000154262
  • ENST00000590645
  • ENSP00000466862

Symbol
  • EST155051
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
cell type or tissue
0.88
protein domain
0.73
gene perturbation
0.58
cell line
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.74   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.74   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
1
7
98.1
sex hormone-binding globulin measurement
3
2
3
95.1
total cholesterol measurement
3
1
4
88.7
hemoglobin measurement
3
1
3
82.8
hematocrit
3
1
3
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
98.1
sex hormone-binding globulin measurement
3
95.1
total cholesterol measurement
4
88.7
hemoglobin measurement
3
82.8
hematocrit
3
81.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 6
VGNC:6319
742817
Mouse
MGI:1923434
76184
Rat
RGD:1308998
303639
Horse
ATP binding cassette subfamily A member 6
VGNC:14905
100062487
Cow
ATP binding cassette subfamily A member 6
VGNC:25460
537351
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 6
Mouse
Rat
Horse
ATP binding cassette subfamily A member 6
Cow
ATP binding cassette subfamily A member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N139-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene expression (Transcription)
Protein-Protein Interactions (23)
1 – 10 of 23
ABCF3
Tdark
Family: Transporter
Novelty: 0.21595418
Score: 0.605
Data Source: STRINGDB
SRRM1
Tbio
Novelty: 0.03770186
Score: 0.554
Data Source: STRINGDB
SLC22A8
Tclin
Family: Transporter
Novelty: 0.00291642
Score: 0.55
Data Source: STRINGDB
ABCD4
Tbio
Family: Transporter
Novelty: 0.04096359
Score: 0.532
Data Source: STRINGDB
ABCC3
Tbio
Family: Transporter
Novelty: 0.00260166
Score: 0.494
Data Source: STRINGDB
ABCF1
Tbio
Family: Transporter
Novelty: 0.03900964
Score: 0.474
Data Source: STRINGDB
FABP12
Tdark
Novelty: 0.21616135
Score: 0.474
Data Source: STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.469
Data Source: STRINGDB
CDAN1
Tbio
Novelty: 0.00610604
Score: 0.451
Data Source: STRINGDB
DCAF4L1
Tdark
Novelty: 4.17944542
Score: 0.44
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.74

PubMed score by year
PubTator Score  6.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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