Tbio ORMDL3 ORM1-like protein 3

Protein Summary

Description

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

Uniprot Accession IDs

• Q8N138
• B3KS83
• Q6UY83

Gene Name

• ORMDL3

Ensembl ID

• ENST00000304046
• ENSP00000304858
• ENSG00000172057
• ENST00000394169
• ENSP00000377724
• ENST00000579695
• ENSP00000464693
• ENST00000584220
• ENSP00000464455

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
cellular component	0.75
histone modification site profile	0.69
tissue sample	0.66
transcription factor	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.54   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.54   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (164)

Explore Interacting Targets

1 – 10 of 164

• See Interactions on String-DB

SLC1A1

Tchem

Family:  Transporter

Novelty:  0.00218479

p_int:  0.99757306

p_ni:  0.000006192

p_wrong:  0.002420748

Data Source:  BioPlex

SLC22A9

Tbio

Family:  Transporter

Novelty:  0.02212992

p_int:  0.978025877

p_ni:  0.000039405

p_wrong:  0.021934718

Score:  0.159

Data Source:  BioPlex,STRINGDB

SPRY4

Tbio

Novelty:  0.01578378

p_int:  0.957789495

p_ni:  3.75e-7

p_wrong:  0.04221013

Score:  0.54

Data Source:  BioPlex,STRINGDB

GABBR1

Tclin

Family:  GPCR

Novelty:  0.00086493

p_int:  0.790244383

p_ni:  0.000257544

p_wrong:  0.209498073

Data Source:  BioPlex

SLC2A12

Tbio

Family:  Transporter

Novelty:  0.01455533

p_int:  0.77692198

p_ni:  0.000003303

p_wrong:  0.223074718

Score:  0.16

Data Source:  BioPlex,STRINGDB

SPTLC1

Tchem

Family:  Enzyme

Novelty:  0.00639691

Score:  0.982

Data Source:  STRINGDB

SPTLC2

Tchem

Family:  Enzyme

Novelty:  0.01236952

Score:  0.959

Data Source:  STRINGDB

SPTLC3

Tbio

Family:  Enzyme

Novelty:  0.03671571

Score:  0.938

Data Source:  STRINGDB

C3AR1

Tchem

Family:  GPCR

Novelty:  0.00527301

Score:  0.92

Data Source:  STRINGDB

SPTSSA

Tbio

Family:  Enzyme

Novelty:  0.13352078

Score:  0.92

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (7)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Neutrophil degranulation	543 targets	R-HSA-6798695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Components (6)

Processes (4)

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1 – 6 of 6

GO Term	Evidence	Assigned by
endoplasmic reticulum	Inferred from Direct Assay (IDA)	UniProtKB
SPOTS complex	Inferred from Direct Assay (IDA)	UniProtKB
plasma membrane	Traceable Author Statement (TAS)	Reactome
secretory granule membrane	Traceable Author Statement (TAS)	Reactome
specific granule membrane	Traceable Author Statement (TAS)	Reactome
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (58)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 58

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	11	14	22		99.9
leukocyte count	EFO_0004308	11	14	28		99.8
myeloid white cell count	EFO_0007988	5	7	7		99.6
childhood onset asthma	EFO_0004591	4	6	0	1.3	99.3
asthma	EFO_0000270	16	17	1	1.2	99.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 58

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	22		99.9
leukocyte count	EFO_0004308	28		99.8
myeloid white cell count	EFO_0007988	7		99.6
childhood onset asthma	EFO_0004591	0	1.3	99.3
asthma	EFO_0000270	1	1.2	99.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Asthma
Complete proteome
Endoplasmic reticulum
Membrane
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
acute lymphoblastic leukemia
age at onset
aging
alkaline phosphatase measurement
allergic rhinitis
allergy
asthma
atrial fibrillation
basophil count
basophil percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ORMDL sphingolipid biosynthesis regulator 3	VGNC:9495	746120
Macaque	ORMDL sphingolipid biosynthesis regulator 3		699154
Mouse	ORM1-like 3 (S. cerevisiae)	MGI:1913862	66612
Rat	ORMDL sphingolipid biosynthesis regulator 3	RGD:1560577	360618
Dog	ORMDL sphingolipid biosynthesis regulator 3	VGNC:44147	480530

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ORMDL sphingolipid biosynthesis regulator 3
Macaque	ORMDL sphingolipid biosynthesis regulator 3
Mouse	ORM1-like 3 (S. cerevisiae)
Rat	ORMDL sphingolipid biosynthesis regulator 3
Dog	ORMDL sphingolipid biosynthesis regulator 3

Publication Statistics

PubMed Score 133.54

PubMed score by year

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PubTator Score 74.78

PubTator score by year

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Related Publications

Text Mined References (84)

GeneRif Annotations (60)

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PMID	Year	Title