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Tbio
ORMDL3
ORM1-like protein 3

Protein Summary
Description
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304046
  • ENSP00000304858
  • ENSG00000172057
  • ENST00000394169
  • ENSP00000377724
  • ENST00000579695
  • ENSP00000464693
  • ENST00000584220
  • ENSP00000464455
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
cellular component
0.75
histone modification site profile
0.69
tissue sample
0.66
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.54   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.54   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (58)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
11
14
22
99.9
leukocyte count
11
14
28
99.8
myeloid white cell count
5
7
7
99.6
childhood onset asthma
4
6
0
1.3
99.3
16
17
1
1.2
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
22
99.9
leukocyte count
28
99.8
myeloid white cell count
7
99.6
childhood onset asthma
0
1.3
99.3
1
1.2
99.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ORMDL sphingolipid biosynthesis regulator 3
VGNC:9495
746120
Macaque
ORMDL sphingolipid biosynthesis regulator 3
699154
Mouse
MGI:1913862
66612
Rat
RGD:1560577
360618
Dog
ORMDL sphingolipid biosynthesis regulator 3
VGNC:44147
480530
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ORMDL sphingolipid biosynthesis regulator 3
Macaque
ORMDL sphingolipid biosynthesis regulator 3
Mouse
Rat
Dog
ORMDL sphingolipid biosynthesis regulator 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N138-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Neutrophil degranulation
Gene Ontology Terms (10)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (164)
1 – 10 of 164
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.99757306
p_ni:  0.000006192
p_wrong:  0.002420748
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.978025877
p_ni:  0.000039405
p_wrong:  0.021934718
Score:  0.159
Data Source:  BioPlex,STRINGDB
SPRY4
Tbio
Novelty:  0.01578378
p_int:  0.957789495
p_ni:  3.75e-7
p_wrong:  0.04221013
Score:  0.54
Data Source:  BioPlex,STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
p_int:  0.790244383
p_ni:  0.000257544
p_wrong:  0.209498073
Data Source:  BioPlex
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.77692198
p_ni:  0.000003303
p_wrong:  0.223074718
Score:  0.16
Data Source:  BioPlex,STRINGDB
SPTLC1
Tchem
Family:  Enzyme
Novelty:  0.00639691
Score:  0.982
Data Source:  STRINGDB
SPTLC2
Tchem
Family:  Enzyme
Novelty:  0.01236952
Score:  0.959
Data Source:  STRINGDB
SPTLC3
Tbio
Family:  Enzyme
Novelty:  0.03671571
Score:  0.938
Data Source:  STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.92
Data Source:  STRINGDB
SPTSSA
Tbio
Family:  Enzyme
Novelty:  0.13352078
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  133.54

PubMed score by year
PubTator Score  74.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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