Tbio CNTROB Centrobin

Protein Summary

Description

Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q8N137
• A6NHQ1
• Q331K3
• Q69YV7
• Q8NCB8
• Q8WXV3
• Q96CQ7
• Q9C060

Gene Name

• CNTROB

Ensembl ID

• ENST00000380262
• ENSP00000369614
• ENSG00000170037
• ENST00000563694
• ENSP00000456335
• ENST00000565740
• ENSP00000454840

Symbol

• LIP8
• LIP8
• PP1221

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.71
transcription factor binding site profile	0.58
cellular component	0.56
tissue	0.56
tissue sample	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.51   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.51   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0