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Tbio
TMEM123
Porimin

Protein Summary
Description
Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361236
  • ENSP00000355285
  • ENSG00000152558
  • ENST00000398136
  • ENSP00000381204

Symbol
  • KCT3
  • KCT3
  • PORMIN
  • PORIMIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
cell type or tissue
0.72
cell line
0.69
virus perturbation
0.68
PubMedID
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 7 measurement
1
3
3
96.3
matrix metalloproteinase 1 measurement
1
1
1
64.4
prostate specific antigen measurement
1
1
1
51.7
diastolic blood pressure
2
1
2
40.7
2
1
0
1.1
34.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 7 measurement
3
96.3
matrix metalloproteinase 1 measurement
1
64.4
prostate specific antigen measurement
1
51.7
diastolic blood pressure
2
40.7
0
1.1
34.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 123
VGNC:983
740255
Mouse
MGI:1919179
71929
Rat
RGD:1305625
363013
Dog
uncharacterized LOC100856041
100856041
Opossum
transmembrane protein 123
103094183
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 123
Mouse
Rat
Dog
uncharacterized LOC100856041
Opossum
transmembrane protein 123
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N131-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (17)
1 – 10 of 17
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.999384367
p_ni:  0.000615578
p_wrong:  5.5e-8
Score:  0.338
Data Source:  BioPlex,STRINGDB
BAG2
Tbio
Novelty:  0.00924011
Score:  0.807
Data Source:  STRINGDB
DNAJC6
Tbio
Family:  Enzyme
Novelty:  0.01359669
Score:  0.764
Data Source:  STRINGDB
PPIH
Tbio
Family:  Enzyme
Novelty:  0.03225561
Score:  0.719
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.677
Data Source:  STRINGDB
CCAR2
Tbio
Novelty:  0.07397743
Score:  0.677
Data Source:  STRINGDB
PCNP
Tbio
Novelty:  0.07643705
Score:  0.665
Data Source:  STRINGDB
ZNF112
Tdark
Family:  TF
Novelty:  0.9242381
Score:  0.545
Data Source:  STRINGDB
WFDC13
Tdark
Novelty:  0.32518794
Score:  0.532
Data Source:  STRINGDB
WDR77
Tbio
Novelty:  0.03052382
Score:  0.523
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.08

PubMed score by year
PubTator Score  6.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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