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Tbio
SLC34A3
Sodium-dependent phosphate transport protein 2C

Protein Summary
Description
May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx. This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361134
  • ENSP00000355353
  • ENSG00000198569
  • ENST00000538474
  • ENSP00000442397

Symbol
  • NPT2C
  • NPTIIC
  • HHRH
  • NPTIIc
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
cell type or tissue
0.56
transcription factor
0.52
cell line
0.51
metabolite
0.45


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
89.1
creatinine measurement
1
2
2
86.1
reticulocyte measurement
3
1
3
82.3
reticulocyte count
6
1
6
80.4
serum urea measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
89.1
creatinine measurement
2
86.1
reticulocyte measurement
3
82.3
reticulocyte count
6
80.4
serum urea measurement
1
54.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2159410
142681
Rat
RGD:708551
246234
Dog
solute carrier family 34 member 3
VGNC:49753
491232
Horse
solute carrier family 34 member 3 [Source:HGNC Symbol;Acc:HGNC:20305]
Cow
solute carrier family 34 member 3 [Source:HGNC Symbol;Acc:HGNC:20305]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
solute carrier family 34 member 3
Horse
solute carrier family 34 member 3 [Source:HGNC Symbol;Acc:HGNC:20305]
Cow
solute carrier family 34 member 3 [Source:HGNC Symbol;Acc:HGNC:20305]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N130-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) (R-HSA-5619097)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Protein-Protein Interactions (35)
1 – 10 of 35
FGF23
Tclin
Novelty:  0.00047318
Score:  0.835
Data Source:  STRINGDB
SLC20A2
Tbio
Family:  Transporter
Novelty:  0.00387767
Score:  0.817
Data Source:  STRINGDB
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
Score:  0.759
Data Source:  STRINGDB
KL
Tbio
Family:  Enzyme
Novelty:  0.00096954
Score:  0.736
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.705
Data Source:  STRINGDB
CYP27B1
Tchem
Family:  Enzyme
Novelty:  0.00147574
Score:  0.705
Data Source:  STRINGDB
PHEX
Tbio
Family:  Enzyme
Novelty:  0.00258726
Score:  0.701
Data Source:  STRINGDB
CYP24A1
Tchem
Family:  Enzyme
Novelty:  0.00107155
Score:  0.676
Data Source:  STRINGDB
DMP1
Tbio
Novelty:  0.03114505
Score:  0.675
Data Source:  STRINGDB
PDZK1
Tbio
Novelty:  0.01129974
Score:  0.67
Data Source:  STRINGDB
Publication Statistics
PubMed Score  51.44

PubMed score by year
PubTator Score  29.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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