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Tdark
FAM177A1
Protein FAM177A1

Protein Summary
Description
This gene encodes a member of a conserved protein family. Alternative splicing results in multiple transcript variants. This gene is thought to be associated with susceptibility to juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280987
  • ENSP00000280987
  • ENSG00000151327
  • ENST00000382406
  • ENSP00000371843
  • ENST00000396472
  • ENSP00000379734

Symbol
  • C14orf24
  • C14orf24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
microRNA
0.62
tissue sample
0.62
cell line
0.53
tissue
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
74.7
lymphocyte count
2
2
2
61
monocyte percentage of leukocytes
2
2
2
59.6
C-reactive protein measurement
1
1
1
53.8
monocyte count
1
1
1
43.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
74.7
lymphocyte count
2
61
monocyte percentage of leukocytes
2
59.6
C-reactive protein measurement
1
53.8
monocyte count
1
43.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 177 member A1
453239
Mouse
MGI:1920635
73385
Rat
RGD:2323636
100359558
Dog
family with sequence similarity 177 member A1
VGNC:49745
100686710
Horse
family with sequence similarity 177 member A1
VGNC:49360
100050727
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 177 member A1
Mouse
Rat
Dog
family with sequence similarity 177 member A1
Horse
family with sequence similarity 177 member A1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N128-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (40)
1 – 10 of 40
CLCN7
Tchem
Family: IC
Novelty: 0.00764796
p_int: 0.999848897
p_ni: 0.000151103
Data Source: BioPlex
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.999020158
p_ni: 0.000977978
p_wrong: 0.000001865
Data Source: BioPlex
RHOJ
Tbio
Family: Enzyme
Novelty: 0.01217051
p_int: 0.99719946
p_ni: 0.002800539
Score: 0.179
Data Source: BioPlex,STRINGDB
FAM204A
Tdark
Novelty: 0.74892948
p_int: 0.996654703
p_ni: 0.003282926
p_wrong: 0.000062372
Score: 0.217
Data Source: BioPlex,STRINGDB
SLC27A2
Tbio
Family: Transporter
Novelty: 0.01436035
p_int: 0.991186157
p_ni: 0.008813843
Data Source: BioPlex
VPS13B
Tbio
Novelty: 0.02154769
p_int: 0.987149993
p_ni: 0.012850007
Score: 0.202
Data Source: BioPlex,STRINGDB
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.981973289
p_ni: 0.000106335
p_wrong: 0.017920376
Score: 0.165
Data Source: BioPlex,STRINGDB
GTF2F2
Tbio
Novelty: 0.02446629
p_int: 0.977116422
p_ni: 0.000254204
p_wrong: 0.022629374
Score: 0.277
Data Source: BioPlex,STRINGDB
FAM207A
Tdark
Novelty: 0.62803282
p_int: 0.955558657
p_ni: 0.044441343
Score: 0.179
Data Source: BioPlex,STRINGDB
TGS1
Tbio
Family: Enzyme
Novelty: 0.03390504
p_int: 0.947313715
p_ni: 0.052682411
p_wrong: 0.000003874
Score: 0.191
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.25

PubMed score by year
PubTator Score  1.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer