Tbio CADM3 Cell adhesion molecule 3

Protein Summary

Description

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q8N126
• Q8IZQ9
• Q9NVJ5
• Q9UJP1

Gene Name

• CADM3

Ensembl ID

• ENST00000368124
• ENSP00000357106
• ENSG00000162706
• ENST00000368125
• ENSP00000357107

Symbol

• IGSF4B
• NECL1
• SYNCAM3
• TSLL1
• BIgR
• NECL1
• TSLL1
• IGSF4B
• Necl-1
• synCAM3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor perturbation	0.68
virus perturbation	0.64
PubMedID	0.6
microRNA	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.95   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.95   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0