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Tbio
CADM3
Cell adhesion molecule 3

Protein Summary
Description
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368124
  • ENSP00000357106
  • ENSG00000162706
  • ENST00000368125
  • ENSP00000357107

Symbol
  • IGSF4B
  • NECL1
  • SYNCAM3
  • TSLL1
  • BIgR
  • NECL1
  • TSLL1
  • IGSF4B
  • Necl-1
  • synCAM3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.68
virus perturbation
0.64
PubMedID
0.6
microRNA
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.83   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.83   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (83)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
8
6
14
15.6
99.4
C-reactive protein measurement
3
11
11
99
neutrophil count
7
5
12
98.6
granulocyte count
2
6
7
98.5
myeloid white cell count
4
3
6
98.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
14
15.6
99.4
C-reactive protein measurement
11
99
neutrophil count
12
98.6
granulocyte count
7
98.5
myeloid white cell count
6
98.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule 3
VGNC:460
457426
Macaque
cell adhesion molecule 3
719985
Mouse
MGI:2137858
94332
Rat
RGD:1307035
360882
Dog
cell adhesion molecule 3
VGNC:38657
610435
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule 3
Macaque
cell adhesion molecule 3
Mouse
Rat
Dog
cell adhesion molecule 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N126-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Nectin/Necl trans heterodimerization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Nectin/Necl trans heterodimerization
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
HGNC
Protein-Protein Interactions (72)
1 – 10 of 72
NECTIN3
Tbio
Novelty:  0.01288113
Score:  0.928
Data Source:  Reactome,STRINGDB
NECTIN1
Tbio
Novelty:  0.00348549
Score:  0.921
Data Source:  Reactome,STRINGDB
CADM1
Tbio
Novelty:  0.00103391
Score:  0.916
Data Source:  Reactome,STRINGDB
MPP6
Tbio
Novelty:  0.08883057
Score:  0.73
Data Source:  STRINGDB
NRXN2
Tbio
Novelty:  0.01252742
Score:  0.715
Data Source:  STRINGDB
NRXN2
Tbio
Novelty:  0.01252742
Score:  0.715
Data Source:  STRINGDB
SPTA1
Tbio
Novelty:  0.00456741
Score:  0.695
Data Source:  STRINGDB
MPP3
Tbio
Novelty:  0.0284013
Score:  0.665
Data Source:  STRINGDB
UBE2QL1
Tbio
Novelty:  0.30511261
Score:  0.639
Data Source:  STRINGDB
CNTN2
Tbio
Novelty:  0.00213251
Score:  0.63
Data Source:  STRINGDB
Publication Statistics
PubMed Score  52.83

PubMed score by year
PubTator Score  17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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