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Tbio
TAGAP
T-cell activation Rho GTPase-activating protein

Protein Summary
Description
May function as a GTPase-activating protein and may play important roles during T-cell activation. This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326965
  • ENSP00000322650
  • ENSG00000164691
  • ENST00000338313
  • ENSP00000340217
  • ENST00000367066
  • ENSP00000356033

Symbol
  • TAGAP1
  • FKSG15
  • IDDM21
  • TAGAP1
  • ARHGAP47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.74
virus perturbation
0.72
cell type or tissue
0.7
phenotype
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.61   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.61   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
85.9
myeloid white cell count
1
1
1
78.7
1
1
0
1.2
72.6
lipoprotein A measurement
1
1
1
51.2
neutrophil count
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.9
myeloid white cell count
1
78.7
0
1.2
72.6
lipoprotein A measurement
1
51.2
neutrophil count
1
21
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T cell activation RhoGTPase activating protein
VGNC:3722
463105
Macaque
T-cell activation RhoGTPase activating protein
701690
Mouse
MGI:3615484
72536
Rat
RGD:1308618
308097
Dog
T cell activation RhoGTPase activating protein
VGNC:47092
484059
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T cell activation RhoGTPase activating protein
Macaque
T-cell activation RhoGTPase activating protein
Mouse
Rat
Dog
T cell activation RhoGTPase activating protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N103-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (162)
1 – 10 of 162
SNTB1
Tbio
Novelty: 0.05324344
p_int: 0.999929609
p_ni: 0.000070391
Data Source: BioPlex
UTRN
Tbio
Novelty: 0.0018541
p_int: 0.999870122
p_ni: 0.000129877
p_wrong: 1e-9
Data Source: BioPlex
DTNA
Tbio
Novelty: 0.01165754
p_int: 0.999803303
p_ni: 0.000196669
p_wrong: 2.8e-8
Data Source: BioPlex
SNTB2
Tbio
Novelty: 0.05469501
p_int: 0.999655526
p_ni: 0.000344474
Data Source: BioPlex
DTNB
Tbio
Novelty: 0.0586565
p_int: 0.998111448
p_ni: 0.001857992
p_wrong: 0.00003056
Data Source: BioPlex
SNTA1
Tbio
Novelty: 0.01668288
p_int: 0.997199508
p_ni: 0.002798783
p_wrong: 0.000001709
Data Source: BioPlex
CTNNAL1
Tbio
Novelty: 0.03667606
p_int: 0.99164263
p_ni: 0.00798828
p_wrong: 0.00036909
Data Source: BioPlex
RPS6KA2
Tchem
Family: Kinase
Novelty: 0.00409407
p_int: 0.913336798
p_ni: 0.08265458
p_wrong: 0.004008622
Data Source: BioPlex
BLK
Tchem
Family: Kinase
Novelty: 0.00480349
p_int: 0.886837831
p_ni: 0.110105615
p_wrong: 0.003056554
Score: 0.358
Data Source: BioPlex,STRINGDB
RHOH
Tbio
Family: Enzyme
Novelty: 0.00882842
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.61

PubMed score by year
PubTator Score  15.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer