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Tbio
TTC5
Tetratricopeptide repeat protein 5

Protein Summary
Description
Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258821
  • ENSP00000258821
  • ENSG00000136319

Symbol
  • Strap
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
transcription factor perturbation
0.74
transcription factor binding site profile
0.63
histone modification site profile
0.59
transcription factor
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Methylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Methylation
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (45)
1 – 10 of 45
TUBB
Tclin
Novelty: 0.0038007
p_int: 0.999777163
p_ni: 0.000222837
Score: 0.554
Data Source: BioPlex,STRINGDB
ZBTB9
Tdark
Novelty: 0.95590016
p_int: 0.99900856
p_ni: 0.000991439
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
TUBB2B
Tclin
Novelty: 0.02905844
p_int: 0.996096882
p_ni: 0.003903118
Score: 0.607
Data Source: BioPlex,STRINGDB
TUBB2A
Tclin
Novelty: 0.00902924
p_int: 0.995830699
p_ni: 0.004169301
Score: 0.528
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.99546699
p_ni: 0.00453301
Data Source: BioPlex
TUBA1A
Tchem
Novelty: 0.01030145
p_int: 0.993048234
p_ni: 0.006951766
Score: 0.541
Data Source: BioPlex,STRINGDB
PLPPR2
Tdark
Family: Enzyme
Novelty: 1.03318406
p_int: 0.992453771
p_ni: 0.007546229
Data Source: BioPlex
TCP11L2
Tdark
Novelty: 1.78903335
p_int: 0.991445187
p_ni: 0.000660761
p_wrong: 0.007894051
Score: 0.826
Data Source: BioPlex,STRINGDB
NLGN2
Tbio
Family: Enzyme
Novelty: 0.01613168
p_int: 0.989387465
p_ni: 0.001993133
p_wrong: 0.008619403
Score: 0.179
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.986563082
p_ni: 0.013436918
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.60

PubMed score by year
PubTator Score  4.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer