Tbio TTC5 Tetratricopeptide repeat protein 5

Protein Summary

Description

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

Uniprot Accession IDs

• Q8N0Z6
• A8MQ18
• Q96HF9
• TPR repeat protein 5

Gene Name

• TTC5

Ensembl ID

• ENST00000258821
• ENSP00000258821
• ENSG00000136319

Symbol

• Strap

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.88
transcription factor perturbation	0.74
transcription factor binding site profile	0.63
histone modification site profile	0.59
transcription factor	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.1   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.1   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0