Tbio ABRA Actin-binding Rho-activating protein

Protein Summary

Description

Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.

Uniprot Accession IDs

• Q8N0Z2

Gene Name

• ABRA

Ensembl ID

• ENST00000311955
• ENSP00000311436
• ENSG00000174429

Symbol

• STARS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.72
gene perturbation	0.68
microRNA	0.64
interacting protein	0.58
cellular component	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.49   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.49   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0