Tbio SPART Spartin

Protein Summary

Description

May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q8N0X7
• O60349
• Q86Y67
• Q9H1T2
• Q9H1T3

Gene Name

• SPART

Ensembl ID

• ENST00000355182
• ENSP00000347314
• ENSG00000133104
• ENST00000438666
• ENSP00000406061
• ENST00000451493
• ENSP00000414147
• ENST00000494062
• ENSP00000473599
• ENST00000650221
• ENSP00000497209

Symbol

• KIAA0610
• SPG20
• TAHCCP1
• SPG20
• TAHCCP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Related Tools

GlyGen

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.09   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.09   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	spartin	VGNC:14856	452538
Macaque	spartin		693663
Mouse	spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)	MGI:2139806	229285
Dog	spartin	VGNC:46702	477303
Horse	spartin	VGNC:23480	100062426

Species	Name	OMA	EggNOG	Inparanoid
Chimp	spartin
Macaque	spartin
Mouse	spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)
Dog	spartin
Horse	spartin

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N0X7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (2)

KEGG (1)

PathwayCommons (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144

Gene Ontology Terms (16)

Functions (1)

Components (7)

Processes (8)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB

Protein-Protein Interactions (168)

Explore Interacting Targets

1 – 10 of 168

• See Interactions on String-DB

POLK

Tbio

Family: Enzyme

Novelty: 0.01378154

p_int: 0.99999967

p_ni: 3.3e-7

Score: 0.282

Data Source: BioPlex,STRINGDB

SMURF1

Tchem

Family: Enzyme

Novelty: 0.00754708

p_int: 0.998923014

p_ni: 0.001076986

p_wrong: 1e-9

Score: 0.372

Data Source: BioPlex,STRINGDB

ITCH

Tbio

Family: Enzyme

Novelty: 0.00681861

p_int: 0.987605414

p_ni: 0.012394586

Score: 0.706

Data Source: BioPlex,STRINGDB

WWP1

Tbio

Family: Enzyme

Novelty: 0.01407874

p_int: 0.980780736

p_ni: 0.019219264

Score: 0.653

Data Source: BioPlex,STRINGDB

HECW2

Tbio

Family: Enzyme

Novelty: 0.07194044

p_int: 0.971720159

p_ni: 0.028279804

p_wrong: 3.6e-8

Score: 0.221

Data Source: BioPlex,STRINGDB

EPS15

Tbio

Novelty: 0.00451447

Score: 0.947

Data Source: STRINGDB

IST1

Tbio

Novelty: 0.01780503

Score: 0.925

Data Source: STRINGDB

NIPA1

Tbio

Novelty: 0.02398766

Score: 0.87

Data Source: STRINGDB

TRIM45

Tbio

Novelty: 0.03874681

Score: 0.864

Data Source: STRINGDB

SORBS1

Tbio

Novelty: 0.01480301

Score: 0.838

Data Source: STRINGDB

Publication Statistics

PubMed Score  78.09

PubMed score by year

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PubTator Score  28.31

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Hereditary spastic paraplegia
Isopeptide bond
Neurodegeneration
Phosphoprotein
Reference proteome

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
mortality/aging
neoplasm
nervous system phenotype
skeleton phenotype