Tbio SPART Spartin

Protein Summary

Description

May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q8N0X7
• O60349
• Q86Y67
• Q9H1T2
• Q9H1T3

Gene Name

• SPART

Ensembl ID

• ENST00000355182
• ENSP00000347314
• ENSG00000133104
• ENST00000438666
• ENSP00000406061
• ENST00000451493
• ENSP00000414147
• ENST00000494062
• ENSP00000473599
• ENST00000650221
• ENSP00000497209

Symbol

• KIAA0610
• SPG20
• TAHCCP1
• SPG20
• TAHCCP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.3   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.3   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0