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Tbio
SPART
Spartin

Protein Summary
Description
May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355182
  • ENSP00000347314
  • ENSG00000133104
  • ENST00000438666
  • ENSP00000406061
  • ENST00000451493
  • ENSP00000414147
  • ENST00000494062
  • ENSP00000473599
  • ENST00000650221
  • ENSP00000497209

Symbol
  • KIAA0610
  • SPG20
  • TAHCCP1
  • SPG20
  • TAHCCP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.43   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.43   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
POLK
Tbio
Family:  Enzyme
Novelty:  0.01378154
p_int:  0.99999967
p_ni:  3.3e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
SMURF1
Tchem
Family:  Enzyme
Novelty:  0.00754708
p_int:  0.998923014
p_ni:  0.001076986
p_wrong:  1e-9
Score:  0.372
Data Source:  BioPlex,STRINGDB
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
p_int:  0.987605414
p_ni:  0.012394586
Score:  0.706
Data Source:  BioPlex,STRINGDB
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
p_int:  0.980780736
p_ni:  0.019219264
Score:  0.653
Data Source:  BioPlex,STRINGDB
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
p_int:  0.971720159
p_ni:  0.028279804
p_wrong:  3.6e-8
Score:  0.221
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.947
Data Source:  STRINGDB
IST1
Tbio
Novelty:  0.01780503
Score:  0.925
Data Source:  STRINGDB
NIPA1
Tbio
Novelty:  0.02398766
Score:  0.87
Data Source:  STRINGDB
TRIM45
Tbio
Novelty:  0.03874681
Score:  0.864
Data Source:  STRINGDB
SORBS1
Tbio
Novelty:  0.01480301
Score:  0.838
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spartin
VGNC:14856
452538
Macaque
spartin
693663
Mouse
MGI:2139806
229285
Dog
spartin
VGNC:46702
477303
Horse
spartin
VGNC:23480
100062426
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spartin
Macaque
spartin
Mouse
Dog
spartin
Horse
spartin
Publication Statistics
PubMed Score 79.43
PubMed score by year
PubTator Score 28.31
PubTator score by year
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Related Publications
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PMID
Year
Title