Protein Summary
May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]
- ENST00000355182
- ENSP00000347314
- ENSG00000133104
- ENST00000438666
- ENSP00000406061
- ENST00000451493
- ENSP00000414147
- ENST00000494062
- ENSP00000473599
- ENST00000650221
- ENSP00000497209
- KIAA0610
- SPG20
- TAHCCP1
- SPG20
- TAHCCP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.43 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 187 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.43 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 187 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (168)
POLK
Family: Enzyme
Novelty: 0.01378154
p_int: 0.99999967
p_ni: 3.3e-7
Score: 0.282
Data Source: BioPlex,STRINGDB
SMURF1
Family: Enzyme
Novelty: 0.00754708
p_int: 0.998923014
p_ni: 0.001076986
p_wrong: 1e-9
Score: 0.372
Data Source: BioPlex,STRINGDB
ITCH
Family: Enzyme
Novelty: 0.00681861
p_int: 0.987605414
p_ni: 0.012394586
Score: 0.706
Data Source: BioPlex,STRINGDB
WWP1
Family: Enzyme
Novelty: 0.01407874
p_int: 0.980780736
p_ni: 0.019219264
Score: 0.653
Data Source: BioPlex,STRINGDB
HECW2
Family: Enzyme
Novelty: 0.07194044
p_int: 0.971720159
p_ni: 0.028279804
p_wrong: 3.6e-8
Score: 0.221
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
KEGG (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (1)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 1 | 1 | 1 | 1.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
smoking status measurement | 1 | 1.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | spartin | VGNC:14856 | 452538 | |||||
Macaque | spartin | 693663 | ||||||
Mouse | MGI:2139806 | 229285 | ||||||
Dog | spartin | VGNC:46702 | 477303 | |||||
Horse | spartin | VGNC:23480 | 100062426 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | spartin | |||||
Macaque | spartin | |||||
Mouse | ||||||
Dog | spartin | |||||
Horse | spartin | |||||
Publication Statistics
PubMed Score 79.43
PubMed score by year
PubTator Score 28.31
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
---|