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Tbio
NLGN4X
Neuroligin-4, X-linked

Protein Summary
Description
Putative neuronal cell surface protein involved in cell-cell-interactions. This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275857
  • ENSP00000275857
  • ENSG00000146938
  • ENST00000381092
  • ENSP00000370482
  • ENST00000381093
  • ENSP00000370483
  • ENST00000381095
  • ENSP00000370485
  • ENST00000538097
  • ENSP00000439203

Symbol
  • KIAA1260
  • NLGN4
  • HLNX
  • HNL4X
  • NLGN4
  • ASPGX2
  • AUTSX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.66
microRNA
0.63
tissue sample
0.63
cellular component
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.55   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.55   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
55.8
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuroligin 4 X-linked
VGNC:2692
465474
Macaque
neuroligin 4, X-linked
106995148
Dog
neuroligin 4, X-linked
607406
Horse
neuroligin 4, X-linked
100050709
Opossum
neuroligin 4, X-linked
100018813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuroligin 4 X-linked
Macaque
neuroligin 4, X-linked
Dog
neuroligin 4, X-linked
Horse
neuroligin 4, X-linked
Opossum
neuroligin 4, X-linked
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N0W4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (37)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (152)
1 – 10 of 152
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
p_int:  1
Score:  0.945
Data Source:  BioPlex,STRINGDB
NRXN3
Tbio
Novelty:  0.00999084
Score:  0.997
Data Source:  STRINGDB
NRXN2
Tbio
Novelty:  0.01252742
Score:  0.997
Data Source:  STRINGDB
NRXN2
Tbio
Novelty:  0.01252742
Score:  0.997
Data Source:  STRINGDB
NRXN1
Tbio
Novelty:  0.00454659
Score:  0.997
Data Source:  STRINGDB
NRXN1
Tbio
Novelty:  0.00454659
Score:  0.997
Data Source:  STRINGDB
NRXN3
Tbio
Novelty:  0.00999084
Score:  0.997
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.988
Data Source:  STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.976
Data Source:  STRINGDB
SHANK1
Tbio
Novelty:  0.01475447
Score:  0.969
Data Source:  STRINGDB
Publication Statistics
PubMed Score  104.55

PubMed score by year
PubTator Score  33.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer