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Tbio
VKORC1L1
Vitamin K epoxide reductase complex subunit 1-like protein 1

Protein Summary
Description
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360768
  • ENSP00000353998
  • ENSG00000196715
  • ENST00000434382
  • ENSP00000403077
  • ENST00000648179
  • ENSP00000497394
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
cell type or tissue
0.76
tissue sample
0.72
cellular component
0.67
kinase perturbation
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.66   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.66   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.893741937
p_ni:  0.106156896
p_wrong:  0.000101167
Score:  0.204
Data Source:  BioPlex,STRINGDB
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.826282126
p_ni:  0.173706503
p_wrong:  0.000011371
Data Source:  BioPlex
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.803174007
p_ni:  0.196731716
p_wrong:  0.000094277
Data Source:  BioPlex
BBS10
Tbio
Novelty:  0.03343798
Score:  0.985
Data Source:  STRINGDB
CCT2
Tbio
Novelty:  0.01967139
Score:  0.935
Data Source:  STRINGDB
CCT4
Tbio
Novelty:  0.01176123
Score:  0.921
Data Source:  STRINGDB
CCT7
Tbio
Novelty:  0.02247038
Score:  0.91
Data Source:  STRINGDB
CCT3
Tbio
Novelty:  0.01642521
Score:  0.899
Data Source:  STRINGDB
CCT5
Tbio
Novelty:  0.02369118
Score:  0.877
Data Source:  STRINGDB
PCYT1B
Tbio
Family:  Enzyme
Novelty:  0.02972878
Score:  0.822
Data Source:  STRINGDB
Pathways (6)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamin K
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamin K
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
60.2
alkaline phosphatase measurement
1
1
1
13.3
glomerular filtration rate
1
1
1
12.7
intraocular pressure measurement
1
1
0
6
7.2
corneal topography
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
60.2
alkaline phosphatase measurement
1
13.3
glomerular filtration rate
1
12.7
intraocular pressure measurement
0
6
7.2
corneal topography
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
vitamin K epoxide reductase complex subunit 1 like 1
697591
Mouse
MGI:1916818
69568
Rat
RGD:9409402
103693015
Pig
vitamin K epoxide reductase complex subunit 1 like 1
100518062
Opossum
vitamin K epoxide reductase complex subunit 1 like 1
100010095
Species
Name
OMA
EggNOG
Inparanoid
Macaque
vitamin K epoxide reductase complex subunit 1 like 1
Mouse
Rat
Pig
vitamin K epoxide reductase complex subunit 1 like 1
Opossum
vitamin K epoxide reductase complex subunit 1 like 1
Publication Statistics
PubMed Score 8.66
PubMed score by year
PubTator Score 6.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title