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Tbio
CENPL
Centromere protein L

Protein Summary
Description
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345664
  • ENSP00000323543
  • ENSG00000120334
  • ENST00000356198
  • ENSP00000348527
  • ENST00000367710
  • ENSP00000356683

Symbol
  • C1orf155
  • ICEN33
  • CENP-L
  • C1orf155
  • dJ383J4.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.88
transcription factor
0.65
tissue
0.62
tissue sample
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
68
red blood cell density measurement
1
1
1
66
alcohol consumption measurement
3
1
3
56.4
hemoglobin measurement
2
1
2
54.4
hematocrit
2
1
2
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
68
red blood cell density measurement
1
66
alcohol consumption measurement
3
56.4
hemoglobin measurement
2
54.4
hematocrit
2
53.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein L
VGNC:492
457526
Macaque
centromere protein L
707211
Mouse
MGI:1917704
70454
Rat
RGD:1311868
289150
Dog
centromere protein L
VGNC:39107
611220
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein L
Macaque
centromere protein L
Mouse
Rat
Dog
centromere protein L
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N0S6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (165)
1 – 10 of 165
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.999927726
p_ni:  0.000072274
Data Source:  BioPlex
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.995898884
p_ni:  0.000567492
p_wrong:  0.003533624
Data Source:  BioPlex
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.994603221
p_ni:  0.000385351
p_wrong:  0.005011428
Score:  0.175
Data Source:  BioPlex,STRINGDB
ICK
Tchem
Family:  Kinase
Novelty:  0.00810476
p_int:  0.928488029
p_ni:  0.000943382
p_wrong:  0.070568589
Score:  0.527
Data Source:  BioPlex,STRINGDB
CENPK
Tbio
Novelty:  0.04316098
Score:  0.994
Data Source:  STRINGDB
CENPN
Tbio
Novelty:  0.06923443
Score:  0.993
Data Source:  STRINGDB
CENPH
Tbio
Novelty:  0.02845079
Score:  0.991
Data Source:  STRINGDB
CENPI
Tbio
Novelty:  0.01938121
Score:  0.991
Data Source:  STRINGDB
CENPO
Tbio
Novelty:  0.12059767
Score:  0.989
Data Source:  STRINGDB
CENPT
Tbio
Novelty:  0.03878936
Score:  0.984
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.03

PubMed score by year
PubTator Score  3.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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