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Tbio
SYCE1
Synaptonemal complex central element protein 1

Protein Summary
Description
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343131
  • ENSP00000341282
  • ENSG00000171772
  • ENST00000368517
  • ENSP00000357503

Symbol
  • C10orf94
  • CT76
  • POF12
  • SPGF15
  • C10orf94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
tissue sample
0.6
gene perturbation
0.56
cell line
0.43
transcription factor
0.4


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.35   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.35   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptonemal complex central element protein 1
VGNC:5798
740161
Macaque
synaptonemal complex central element protein 1
703593
Mouse
MGI:1921325
74075
Rat
RGD:1559853
502372
Dog
synaptonemal complex central element protein 1
VGNC:47014
480826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptonemal complex central element protein 1
Macaque
synaptonemal complex central element protein 1
Mouse
Rat
Dog
synaptonemal complex central element protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N0S2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Protein-Protein Interactions (161)
1 – 10 of 161
CCDC122
Tdark
Novelty: 0.4560176
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 1e-9
Data Source: BioPlex
ZC4H2
Tbio
Novelty: 0.04969464
p_int: 0.999999991
p_ni: 9e-9
Data Source: BioPlex
ANKRD26
Tbio
Novelty: 0.02266046
p_int: 0.999999973
p_ni: 2.2e-8
p_wrong: 5e-9
Data Source: BioPlex
FAM193A
Tdark
Novelty: 0.35264727
p_int: 0.999999939
p_ni: 6.1e-8
p_wrong: 1e-9
Data Source: BioPlex
RABGAP1L
Tbio
Family: Enzyme
Novelty: 0.2377644
p_int: 0.999999872
p_ni: 1.29e-7
Data Source: BioPlex
GOLGA4
Tbio
Novelty: 0.01363253
p_int: 0.99999977
p_ni: 2.31e-7
Data Source: BioPlex
TJAP1
Tbio
Novelty: 0.008967
p_int: 0.99999956
p_ni: 4.39e-7
Data Source: BioPlex
ROCK1
Tclin
Family: Kinase
Novelty: 0.00156045
p_int: 0.999999486
p_ni: 5.13e-7
p_wrong: 1e-9
Data Source: BioPlex
CENPF
Tbio
Novelty: 0.00676983
p_int: 0.999999027
p_ni: 9.7e-7
p_wrong: 3e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
LUZP1
Tbio
Novelty: 0.14991475
p_int: 0.999998588
p_ni: 0.000001412
Data Source: BioPlex
Publication Statistics
PubMed Score  17.35

PubMed score by year
PubTator Score  8.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer