Tbio APCDD1 Protein APCDD1

Protein Summary

Description

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q8J025
• B4DUQ0
• B4DZT0
• Q71M25

Gene Name

• APCDD1

Ensembl ID

• ENST00000355285
• ENSP00000347433
• ENSG00000154856

Symbol

• DRAPC1
• HHS
• HTS
• B7323
• HYPT1
• DRAPC1
• FP7019

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
cell type or tissue	0.8
small molecule perturbation	0.77
gene perturbation	0.68
PubMedID	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.65   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.65   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0