You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TAF1L
Transcription initiation factor TFIID subunit 1-like

Protein Classes
Protein Summary
Description
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242310
  • ENSP00000418379
  • ENSG00000122728

Symbol
  • TAF2A2
  • TAF(II)210
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
cell type or tissue
0.81
biological process
0.76
protein domain
0.73
cell line
0.63


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chicken
TATA-box binding protein associated factor 1
CGNC:51656
422204
Xenopus
TATA-box binding protein associated factor 1
XB-GENE-952372
100496377
Zebrafish
ZDB-GENE-030131-5576
555452
C. elegans
173257
Fruitfly
FBgn0010355
40813
Species
Name
OMA
EggNOG
Inparanoid
Chicken
TATA-box binding protein associated factor 1
Xenopus
TATA-box binding protein associated factor 1
Zebrafish
C. elegans
Fruitfly
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IZX4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (183)
1 – 10 of 183
TAF6
Tbio
Novelty:  0.04357176
Score:  0.999
Data Source:  STRINGDB
TAF4
Tbio
Novelty:  0.02101584
Score:  0.998
Data Source:  STRINGDB
TAF9B
Tbio
Novelty:  0.0285313
Score:  0.998
Data Source:  STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.998
Data Source:  STRINGDB
TAF2
Tbio
Novelty:  0.0397428
Score:  0.997
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.996
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.996
Data Source:  STRINGDB
TAF12
Tbio
Novelty:  0.04352637
Score:  0.994
Data Source:  STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.993
Data Source:  STRINGDB
TAF10
Tbio
Novelty:  0.0276004
Score:  0.992
Data Source:  STRINGDB
Publication Statistics
PubMed Score  168.82

PubMed score by year
PubTator Score  4.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer