Tbio TNS4 Tensin-4

Protein Summary

Description

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

Uniprot Accession IDs

• Q8IZW8
• A6NMJ7
• Q71RB7
• Q8WV64
• Q96JV4

Gene Name

• TNS4

Ensembl ID

• ENST00000254051
• ENSP00000254051
• ENSG00000131746

Symbol

• CTEN
• CTEN
• PP14434

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
gene perturbation	0.65
cell type or tissue	0.63
PubMedID	0.61
microRNA	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.79   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.79   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0