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Tbio
RDH10
Retinol dehydrogenase 10

Protein Summary
Description
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240285
  • ENSP00000240285
  • ENSG00000121039

Symbol
  • SDR16C4
  • SDR16C4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
biological process
0.83
gene perturbation
0.81
transcription factor binding site profile
0.79
small molecule perturbation
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.12   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.12   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.974
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.969
Data Source:  STRINGDB
RBP1
Tbio
Novelty:  0.00199929
Score:  0.968
Data Source:  STRINGDB
RLBP1
Tbio
Novelty:  0.00526176
Score:  0.961
Data Source:  Reactome,STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.955
Data Source:  STRINGDB
BCO1
Tbio
Family:  Enzyme
Novelty:  0.00784197
Score:  0.948
Data Source:  STRINGDB
RBP5
Tbio
Novelty:  0.06648663
Score:  0.943
Data Source:  STRINGDB
RBP2
Tbio
Novelty:  0.00823654
Score:  0.941
Data Source:  STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
Score:  0.927
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.922
Data Source:  STRINGDB
Pathways (17)
G alpha (i) signalling events (R-HSA-418594)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
RA biosynthesis pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 10
VGNC:14576
472795
Macaque
retinol dehydrogenase 10
695791
Mouse
MGI:1924238
98711
Rat
RGD:727793
353252
Dog
retinol dehydrogenase 10
VGNC:45452
486998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 10
Macaque
retinol dehydrogenase 10
Mouse
Rat
Dog
retinol dehydrogenase 10
Publication Statistics
PubMed Score 43.12
PubMed score by year
PubTator Score 15.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title