RDH10
Retinol dehydrogenase 10
Protein Summary
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
- ENST00000240285
- ENSP00000240285
- ENSG00000121039
- SDR16C4
- SDR16C4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
biological process | 0.83 | ||
gene perturbation | 0.81 | ||
transcription factor binding site profile | 0.79 | ||
small molecule perturbation | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.12 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 141 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.12 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 141 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (41)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (17)
Reactome (9)
KEGG (2)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | RA biosynthesis pathway | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
RA biosynthesis pathway | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (2)
Components (6)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | retinol dehydrogenase 10 | VGNC:14576 | 472795 | |||||
Macaque | retinol dehydrogenase 10 | 695791 | ||||||
Mouse | MGI:1924238 | 98711 | ||||||
Rat | RGD:727793 | 353252 | ||||||
Dog | retinol dehydrogenase 10 | VGNC:45452 | 486998 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | retinol dehydrogenase 10 | |||||
Macaque | retinol dehydrogenase 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | retinol dehydrogenase 10 | |||||
Publication Statistics
PubMed Score 43.12
PubMed score by year
PubTator Score 15.59
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (13)
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