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Tbio
CACNA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

Protein Summary
Description
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly chara ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288197
  • ENSP00000288197
  • ENSG00000157445
  • ENST00000415676
  • ENSP00000389506
  • ENST00000471363
  • ENSP00000418228
  • ENST00000474759
  • ENSP00000419101
  • ENST00000490478
  • ENSP00000417279
  • ENST00000620722
  • ENSP00000478969

Symbol
  • HSA272268
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
gene perturbation
0.99
molecular function
0.91
PubMedID
0.79
transcription factor
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.07   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.07   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
87.4
lifestyle measurement
1
1
1
80.5
self reported educational attainment
1
1
1
72.8
intelligence
1
2
0
5.6
70.6
3
1
2
1.1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
87.4
lifestyle measurement
1
80.5
self reported educational attainment
1
72.8
intelligence
0
5.6
70.6
2
1.1
58.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit alpha2delta 3
VGNC:7961
460457
Mouse
MGI:1338890
12294
Rat
RGD:631361
306243
Dog
calcium voltage-gated channel auxiliary subunit alpha2delta 3
VGNC:38643
476585
Horse
calcium voltage-gated channel auxiliary subunit alpha2delta 3
VGNC:15989
100059197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit alpha2delta 3
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit alpha2delta 3
Horse
calcium voltage-gated channel auxiliary subunit alpha2delta 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IZS8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
SFSWAP
Tdark
Novelty: 0.2236256
p_int: 0.999923057
p_ni: 0.000076943
Data Source: BioPlex
PAGE2B
Tdark
Novelty: 0.70952249
p_int: 0.996582366
p_ni: 0.001487281
p_wrong: 0.001930354
Data Source: BioPlex
APOE
Tbio
Novelty: 0.00005049
p_int: 0.994237228
p_ni: 0.000892593
p_wrong: 0.004870178
Data Source: BioPlex
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.985754034
p_ni: 0.011462464
p_wrong: 0.002783502
Data Source: BioPlex
GPAA1
Tbio
Novelty: 0.01874575
p_int: 0.976120325
p_ni: 0.023879675
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.973826297
p_ni: 0.024738543
p_wrong: 0.00143516
Data Source: BioPlex
SPCS1
Tbio
Family: Enzyme
Novelty: 0.0731223
p_int: 0.87044838
p_ni: 0.067258996
p_wrong: 0.062292624
Data Source: BioPlex
SPCS2
Tdark
Family: Enzyme
Novelty: 0.21358992
p_int: 0.86839942
p_ni: 0.13160058
Data Source: BioPlex
TMBIM6
Tbio
Novelty: 0.00151958
p_int: 0.835456236
p_ni: 0.164511753
p_wrong: 0.000032012
Data Source: BioPlex
PIGU
Tbio
Novelty: 0.11800036
p_int: 0.791321115
p_ni: 0.208678223
p_wrong: 6.62e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  21.07

PubMed score by year
PubTator Score  13.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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