Tbio ADGRG2 Adhesion G-protein coupled receptor G2

Protein Summary

Description

Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q8IZP9
• B1AWB3
• B1AWB4
• B1AWB6
• B1AWB7
• O00406
• Q14CE0
• Q8IWT2
• Q8IZE4
• Q8IZE5
• Q8IZE6
• Q8IZE7
• Q8IZP3
• Q8IZP4

Gene Name

• ADGRG2

Ensembl ID

• ENST00000340581
• ENSP00000344972
• ENSG00000173698
• ENST00000354791
• ENSP00000346845
• ENST00000356606
• ENSP00000349015
• ENST00000357544
• ENSP00000350152
• ENST00000357991
• ENSP00000350680
• ENST00000360279
• ENSP00000353421
• ENST00000379869
• ENSP00000369198
• ENST00000379873
• ENSP00000369202
• ENST00000379876
• ENSP00000369205
• ENST00000379878
• ENSP00000369207

Symbol

• GPR64
• HE6
• TM7LN2
• HE6
• EDDM6
• GPR64
• CBAVDX
• TM7LN2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.8
cell type or tissue	0.76
PubMedID	0.67
cellular component	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G-protein Coupled Receptor G2

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G-protein Coupled Receptor G2

Protein / ... / Protease / Adhesion G-protein Coupled Receptor G2

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G-protein Coupled Receptor G2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.49   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.49   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0