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Tbio
ADGRG2
Adhesion G-protein coupled receptor G2

Protein Summary
Description
Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340581
  • ENSP00000344972
  • ENSG00000173698
  • ENST00000354791
  • ENSP00000346845
  • ENST00000356606
  • ENSP00000349015
  • ENST00000357544
  • ENSP00000350152
  • ENST00000357991
  • ENSP00000350680
  • ENST00000360279
  • ENSP00000353421
  • ENST00000379869
  • ENSP00000369198
  • ENST00000379873
  • ENSP00000369202
  • ENST00000379876
  • ENSP00000369205
  • ENST00000379878
  • ENSP00000369207

Symbol
  • GPR64
  • HE6
  • TM7LN2
  • HE6
  • EDDM6
  • GPR64
  • CBAVDX
  • TM7LN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.8
cell type or tissue
0.76
PubMedID
0.67
cellular component
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.87   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.87   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
CRISP1
Tbio
Novelty:  0.01350338
Score:  0.647
Data Source:  STRINGDB
SCT
Tbio
Novelty:  0.00070278
Score:  0.576
Data Source:  STRINGDB
SMS
Tchem
Family:  Enzyme
Novelty:  0.02447112
Score:  0.549
Data Source:  STRINGDB
RXFP2
Tbio
Family:  GPCR
Novelty:  0.00932189
Score:  0.537
Data Source:  STRINGDB
LY6G5C
Tdark
Novelty:  0.1353418
Score:  0.522
Data Source:  STRINGDB
VSTM2A
Tbio
Novelty:  0.34891628
Score:  0.505
Data Source:  STRINGDB
RTN4RL2
Tbio
Novelty:  0.05919593
Score:  0.49
Data Source:  STRINGDB
LCN8
Tbio
Novelty:  0.02098116
Score:  0.476
Data Source:  STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
Score:  0.474
Data Source:  STRINGDB
SLC26A9
Tbio
Family:  Transporter
Novelty:  0.0354738
Score:  0.455
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G2
VGNC:2730
465524
Macaque
adhesion G protein-coupled receptor G2
694495
Mouse
MGI:2446854
237175
Rat
RGD:628618
266735
Dog
adhesion G protein-coupled receptor G2
VGNC:37644
491763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G2
Macaque
adhesion G protein-coupled receptor G2
Mouse
Rat
Dog
adhesion G protein-coupled receptor G2
Publication Statistics
PubMed Score 42.87
PubMed score by year
PubTator Score 16.50
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title