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Tbio
ABI1
Abl interactor 1

Protein Summary
Description
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin po ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346832
  • ENSP00000279599
  • ENSG00000136754
  • ENST00000359188
  • ENSP00000352114
  • ENST00000376137
  • ENSP00000365307
  • ENST00000376138
  • ENSP00000365308
  • ENST00000376139
  • ENSP00000365309
  • ENST00000376140
  • ENSP00000365310
  • ENST00000376142
  • ENSP00000365312
  • ENST00000376166
  • ENSP00000365336
  • ENST00000376170
  • ENSP00000365340
  • ENST00000490841
  • ENSP00000440101

Symbol
  • SSH3BP1
  • E3B1
  • ABI-1
  • ABLBP4
  • NAP1BP
  • SSH3BP
  • SSH3BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.86
interacting protein
0.85
transcription factor binding site profile
0.84
virus perturbation
0.83
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.67   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.67   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
0.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abl interactor 1
VGNC:5303
450363
Macaque
abl interactor 1
707698
Mouse
MGI:104913
11308
Rat
RGD:621008
79249
Dog
abl interactor 1
VGNC:37474
607247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abl interactor 1
Macaque
abl interactor 1
Mouse
Rat
Dog
abl interactor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IZP0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (160)
1 – 10 of 160
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999999989
p_ni: 1.2e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
NCKAP1
Tbio
Novelty: 0.03486454
p_int: 0.999999941
p_ni: 6e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.999999602
p_ni: 3.92e-7
p_wrong: 6e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999998187
p_ni: 0.000001813
Score: 0.689
Data Source: BioPlex,STRINGDB
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999979814
p_ni: 0.000020186
Data Source: BioPlex
AMZ1
Tdark
Family: Enzyme
Novelty: 0.246305
p_int: 0.999825181
p_ni: 0.000174816
p_wrong: 4e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
WASF3
Tbio
Novelty: 0.0248378
p_int: 0.999782665
p_ni: 0.000217323
p_wrong: 1.1e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
TIMM50
Tbio
Family: Enzyme
Novelty: 0.0238053
p_int: 0.999761331
p_ni: 0.000234237
p_wrong: 0.000004432
Score: 0.305
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999594658
p_ni: 0.000405342
Score: 0.972
Data Source: BioPlex,STRINGDB
NHSL2
Tdark
Novelty: 4.36275023
p_int: 0.999274579
p_ni: 0.000725358
p_wrong: 6.3e-8
Score: 0.633
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  137.67

PubMed score by year
PubTator Score  99.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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