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Tbio
CDK20
Cyclin-dependent kinase 20

Protein Summary
Description
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325303
  • ENSP00000322343
  • ENSG00000156345
  • ENST00000336654
  • ENSP00000338975
  • ENST00000375871
  • ENSP00000365031
  • ENST00000375883
  • ENSP00000365043
  • ENST00000605159
  • ENSP00000474485

Symbol
  • CCRK
  • CDCH
  • P42
  • CCRK
  • CDCH
  • PNQALRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.76
protein domain
0.73
tissue sample
0.72
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.87   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.87   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
FOXJ1
Tbio
Family:  TF
Novelty:  0.00778536
p_int:  0.999999825
p_ni:  1.46e-7
p_wrong:  2.9e-8
Score:  0.435
Data Source:  BioPlex,STRINGDB
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.999999731
p_ni:  2.69e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.999891572
p_ni:  0.000076037
p_wrong:  0.000032391
Data Source:  BioPlex
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
p_int:  0.999849091
p_ni:  8e-9
p_wrong:  0.000150901
Score:  0.29
Data Source:  BioPlex,STRINGDB
CDK7
Tchem
Family:  Kinase
Novelty:  0.00322814
p_int:  0.999814764
p_ni:  0.000171931
p_wrong:  0.000013304
Score:  0.291
Data Source:  BioPlex,STRINGDB
ACMSD
Tchem
Family:  Enzyme
Novelty:  0.02825532
p_int:  0.992117716
p_ni:  0.004433173
p_wrong:  0.003449112
Score:  0.517
Data Source:  BioPlex,STRINGDB
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.992117716
p_ni:  0.004433173
p_wrong:  0.003449112
Data Source:  BioPlex
CCNH
Tbio
Novelty:  0.00693072
Score:  0.931
Data Source:  STRINGDB
MNAT1
Tbio
Family:  Enzyme
Novelty:  0.02484936
Score:  0.87
Data Source:  STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.842
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 20
VGNC:13864
464574
Macaque
cyclin dependent kinase 20
574316
Mouse
MGI:2145349
105278
Rat
RGD:1305219
364666
Dog
cyclin dependent kinase 20
VGNC:39052
476355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 20
Macaque
cyclin dependent kinase 20
Mouse
Rat
Dog
cyclin dependent kinase 20
Publication Statistics
PubMed Score 87.87
PubMed score by year
PubTator Score 412.56
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title