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Tchem
MCOLN2
Mucolipin-2

Protein Summary
Description
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284027
  • ENSP00000284027
  • ENSG00000153898
  • ENST00000370608
  • ENSP00000359640

Symbol
  • TRPML2
  • TRP-ML2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
histone modification site profile
0.6
phenotype
0.57
tissue
0.49
PubMedID
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.79   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.79   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
ML2-SA1
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mucolipin 2
VGNC:1313
456981
Macaque
mucolipin 2
710909
Mouse
MGI:1915529
68279
Rat
RGD:1308884
292168
Horse
mucolipin 2
VGNC:20042
100052719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mucolipin 2
Macaque
mucolipin 2
Mouse
Rat
Horse
mucolipin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IZK6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Protein-Protein Interactions (65)
1 – 10 of 65
LETMD1
Tbio
Novelty: 0.02790517
p_int: 0.999999385
p_ni: 6.15e-7
Data Source: BioPlex
LY6D
Tbio
Novelty: 0.07032941
p_int: 0.9999983
p_ni: 8e-7
p_wrong: 9.01e-7
Data Source: BioPlex
SHPK
Tbio
Family: Kinase
Novelty: 0.16166855
p_int: 0.99988748
p_ni: 0.00011252
Data Source: BioPlex
SOGA3
Tdark
Novelty: 2.17187131
p_int: 0.999608838
p_ni: 0.000389038
p_wrong: 0.000002124
Data Source: BioPlex
MCOLN1
Tchem
Family: IC
Novelty: 0.00442768
p_int: 0.999472318
p_ni: 0.00003276
p_wrong: 0.000494922
Data Source: BioPlex
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
p_int: 0.988671756
p_ni: 0.000001075
p_wrong: 0.011327169
Score: 0.258
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.979071393
p_ni: 0.016993435
p_wrong: 0.003935172
Data Source: BioPlex
PTPRD
Tbio
Family: Enzyme
Novelty: 0.01059407
p_int: 0.978411839
p_ni: 0.0215881
p_wrong: 6.1e-8
Data Source: BioPlex
MAN2A2
Tbio
Family: Enzyme
Novelty: 0.07098345
p_int: 0.967160549
p_ni: 0.032807889
p_wrong: 0.000031562
Data Source: BioPlex
STX16
Tbio
Novelty: 0.02462523
p_int: 0.95879442
p_ni: 0.000907739
p_wrong: 0.040297841
Data Source: BioPlex
Publication Statistics
PubMed Score  18.79

PubMed score by year
PubTator Score  12.22

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer