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Tbio
IFNL3
Interferon lambda-3

Protein Summary
Description
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expressio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000413851
  • ENSP00000409000
  • ENSG00000197110

Symbol
  • IL28B
  • IL28C
  • ZCYTO22
  • IL28B
  • IL28C
  • IL-28B
  • IL-28C
  • IFN-lambda-3
  • IFN-lambda-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
phenotype
0.52
chemical
0.42
cell line
0.4
tissue
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1639.86   (req: < 5)
Gene RIFs: 512   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1639.86   (req: >= 5)
Gene RIFs: 512   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (105)
1 – 10 of 105
ISG15
Tbio
Novelty: 0.00203781
p_int: 0.757031826
p_ni: 0.000305892
p_wrong: 0.242662282
Score: 0.699
Data Source: BioPlex,STRINGDB
IL10RB
Tbio
Novelty: 0.00880915
Score: 0.995
Data Source: Reactome,STRINGDB
IFNLR1
Tbio
Novelty: 0.01990628
Score: 0.995
Data Source: Reactome,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.939
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.937
Data Source: Reactome,STRINGDB
IFNAR1
Tclin
Novelty: 0.00175488
Score: 0.836
Data Source: STRINGDB
IFNAR2
Tclin
Novelty: 0.00453303
Score: 0.795
Data Source: STRINGDB
IL22RA2
Tbio
Novelty: 0.03455127
Score: 0.778
Data Source: STRINGDB
IL10RA
Tbio
Novelty: 0.00506068
Score: 0.761
Data Source: STRINGDB
IFNGR1
Tbio
Novelty: 0.00417244
Score: 0.759
Data Source: STRINGDB
Publication Statistics
PubMed Score  1639.86

PubMed score by year
PubTator Score  1025.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer