ADGRG4
Adhesion G-protein coupled receptor G4
Protein Summary
Orphan receptor. This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
- ENST00000370652
- ENSP00000359686
- ENSG00000156920
- ENST00000394141
- ENSP00000377697
- ENST00000394143
- ENSP00000377699
- GPR112
- PGR17
- GPR112
- RP1-299I16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
cell line | 0.65 | ||
cell type or tissue | 0.56 | ||
PubMedID | 0.47 | ||
kinase perturbation | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.99 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 37 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.99 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 37 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0