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Tdark
ADGRG4
Adhesion G-protein coupled receptor G4

Protein Summary
Description
Orphan receptor. This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370652
  • ENSP00000359686
  • ENSG00000156920
  • ENST00000394141
  • ENSP00000377697
  • ENST00000394143
  • ENSP00000377699

Symbol
  • GPR112
  • PGR17
  • GPR112
  • RP1-299I16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell line
0.65
cell type or tissue
0.56
PubMedID
0.47
kinase perturbation
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.732
Data Source:  STRINGDB
GABRQ
Tclin
Family:  IC
Novelty:  0.12221217
Score:  0.674
Data Source:  STRINGDB
BCORL1
Tbio
Novelty:  0.03899646
Score:  0.673
Data Source:  STRINGDB
SLC25A43
Tbio
Family:  Transporter
Novelty:  0.21667475
Score:  0.654
Data Source:  STRINGDB
RTL9
Tbio
Novelty:  0.15059774
Score:  0.632
Data Source:  STRINGDB
ZNF280C
Tdark
Novelty:  1.44221127
Score:  0.623
Data Source:  STRINGDB
TBX22
Tbio
Family:  TF
Novelty:  0.00824505
Score:  0.578
Data Source:  STRINGDB
TENM1
Tbio
Novelty:  0.01770087
Score:  0.571
Data Source:  STRINGDB
ELF3
Tbio
Family:  TF
Novelty:  0.00284335
Score:  0.568
Data Source:  STRINGDB
MAP3K15
Tchem
Family:  Kinase
Novelty:  0.12112018
Score:  0.565
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 2.82
PubMed score by year
PubTator Score 1.45
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title