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Tdark
ADGRG4
Adhesion G-protein coupled receptor G4

Protein Summary
Description
Orphan receptor. This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370652
  • ENSP00000359686
  • ENSG00000156920
  • ENST00000394141
  • ENSP00000377697
  • ENST00000394143
  • ENSP00000377699

Symbol
  • GPR112
  • PGR17
  • GPR112
  • RP1-299I16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell line
0.65
cell type or tissue
0.56
PubMedID
0.47
kinase perturbation
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (45)
1 – 10 of 45
GPR150
Tdark
Family: GPCR
Novelty: 1.61864462
Score: 0.732
Data Source: STRINGDB
GABRQ
Tclin
Family: IC
Novelty: 0.01865605
Score: 0.674
Data Source: STRINGDB
BCORL1
Tbio
Novelty: 0.07700778
Score: 0.673
Data Source: STRINGDB
SLC25A43
Tdark
Family: Transporter
Novelty: 0.29759634
Score: 0.654
Data Source: STRINGDB
RTL9
Tdark
Novelty: 0.20373514
Score: 0.632
Data Source: STRINGDB
ZNF280C
Tdark
Novelty: 2.4
Score: 0.623
Data Source: STRINGDB
TBX22
Tbio
Family: TF
Novelty: 0.00885604
Score: 0.578
Data Source: STRINGDB
TENM1
Tbio
Novelty: 0.01326399
Score: 0.571
Data Source: STRINGDB
ELF3
Tbio
Family: TF
Novelty: 0.00360099
Score: 0.568
Data Source: STRINGDB
MAP3K15
Tchem
Family: Kinase
Novelty: 0.0989011
Score: 0.565
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.29

PubMed score by year
PubTator Score  1.45

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer