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Tdark
ADGRG5
Adhesion G-protein coupled receptor G5

Protein Summary
Description
Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340339
  • ENSP00000342981
  • ENSG00000159618
  • ENST00000349457
  • ENSP00000290823

Symbol
  • GPR114
  • PGR27
  • PGR27
  • GPR114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.64
gene perturbation
0.62
tissue sample
0.6
protein domain
0.58
microRNA
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
PLPPR3
Tbio
Family:  Enzyme
Novelty:  0.03836833
p_int:  0.99999528
p_ni:  0.000003297
p_wrong:  0.000001423
Data Source:  BioPlex
TSPAN10
Tdark
Novelty:  0.19962098
p_int:  0.999674336
p_ni:  0.000325659
p_wrong:  6e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
TMEM68
Tdark
Novelty:  0.61508475
p_int:  0.999636515
p_ni:  0.000363473
p_wrong:  1.2e-8
Data Source:  BioPlex
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
p_int:  0.999605933
p_ni:  0.000394008
p_wrong:  5.9e-8
Data Source:  BioPlex
GJC1
Tbio
Novelty:  0.00375192
p_int:  0.999536135
p_ni:  0.000444543
p_wrong:  0.000019322
Data Source:  BioPlex
FZD3
Tbio
Family:  GPCR
Novelty:  0.00964507
p_int:  0.999086792
p_ni:  0.000906767
p_wrong:  0.000006442
Data Source:  BioPlex
SLC6A6
Tbio
Family:  Transporter
Novelty:  0.00333868
p_int:  0.998499778
p_ni:  0.000331699
p_wrong:  0.001168522
Data Source:  BioPlex
EPHB3
Tchem
Family:  Kinase
Novelty:  0.00746779
p_int:  0.998203905
p_ni:  0.001780833
p_wrong:  0.000015262
Score:  0.159
Data Source:  BioPlex,STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
p_int:  0.998124028
p_ni:  0.001864049
p_wrong:  0.000011923
Data Source:  BioPlex
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.997651313
p_ni:  0.002348685
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
61.8
mosaic loss of chromosome Y measurement
2
1
2
50.6
platelet crit
1
1
1
48.5
mean corpuscular hemoglobin concentration
1
1
1
47.7
mean reticulocyte volume
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
61.8
mosaic loss of chromosome Y measurement
2
50.6
platelet crit
1
48.5
mean corpuscular hemoglobin concentration
1
47.7
mean reticulocyte volume
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G5
VGNC:13655
454121
Macaque
adhesion G protein-coupled receptor G5
711378
Mouse
MGI:2685955
382045
Rat
RGD:1305559
307645
Dog
adhesion G protein-coupled receptor G5
VGNC:37647
100686072
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor G5
Macaque
adhesion G protein-coupled receptor G5
Mouse
Rat
Dog
adhesion G protein-coupled receptor G5
Publication Statistics
PubMed Score 2.70
PubMed score by year
PubTator Score 1.87
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title