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Tdark
ADGRG5
Adhesion G-protein coupled receptor G5

Protein Summary
Description
Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340339
  • ENSP00000342981
  • ENSG00000159618
  • ENST00000349457
  • ENSP00000290823

Symbol
  • GPR114
  • PGR27
  • PGR27
  • GPR114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.64
gene perturbation
0.62
tissue sample
0.6
protein domain
0.58
microRNA
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
48.3
mosaic loss of chromosome Y measurement
2
1
2
46.1
platelet crit
1
1
1
21.4
mean reticulocyte volume
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
48.3
mosaic loss of chromosome Y measurement
2
46.1
platelet crit
1
21.4
mean reticulocyte volume
1
18.8
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (99)
1 – 10 of 99
PLPPR3
Tbio
Family: Enzyme
Novelty: 0.03836833
p_int: 0.99999528
p_ni: 0.000003297
p_wrong: 0.000001423
Data Source: BioPlex
TSPAN10
Tdark
Novelty: 0.19962098
p_int: 0.999674336
p_ni: 0.000325659
p_wrong: 6e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
TMEM68
Tdark
Novelty: 0.61508475
p_int: 0.999636515
p_ni: 0.000363473
p_wrong: 1.2e-8
Data Source: BioPlex
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
p_int: 0.999605933
p_ni: 0.000394008
p_wrong: 5.9e-8
Data Source: BioPlex
GJC1
Tbio
Novelty: 0.00375192
p_int: 0.999536135
p_ni: 0.000444543
p_wrong: 0.000019322
Data Source: BioPlex
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
p_int: 0.999086792
p_ni: 0.000906767
p_wrong: 0.000006442
Data Source: BioPlex
SLC6A6
Tbio
Family: Transporter
Novelty: 0.00333868
p_int: 0.998499778
p_ni: 0.000331699
p_wrong: 0.001168522
Data Source: BioPlex
EPHB3
Tchem
Family: Kinase
Novelty: 0.00746779
p_int: 0.998203905
p_ni: 0.001780833
p_wrong: 0.000015262
Score: 0.159
Data Source: BioPlex,STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
p_int: 0.998124028
p_ni: 0.001864049
p_wrong: 0.000011923
Data Source: BioPlex
REEP6
Tbio
Novelty: 0.10645981
p_int: 0.997651313
p_ni: 0.002348685
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  2.70

PubMed score by year
PubTator Score  1.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer