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Tbio
ADGRF5
Adhesion G protein-coupled receptor F5

Protein Summary
Description
Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265417
  • ENSP00000265417
  • ENSG00000069122
  • ENST00000283296
  • ENSP00000283296

Symbol
  • GPR116
  • KIAA0758
  • GPR116
  • KPG_001
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cell type or tissue
0.83
transcription factor perturbation
0.74
PubMedID
0.68
phenotype
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
80.4
myeloid white cell count
1
1
1
75.2
neutrophil count
2
1
2
62.7
mean platelet volume
2
2
2
60.8
red blood cell density measurement
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
80.4
myeloid white cell count
1
75.2
neutrophil count
2
62.7
mean platelet volume
2
60.8
red blood cell density measurement
1
43.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor F5
VGNC:8156
739480
Macaque
adhesion G protein-coupled receptor F5
704887
Mouse
MGI:2182928
224792
Rat
RGD:621679
245977
Dog
adhesion G protein-coupled receptor F5
VGNC:37642
474926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor F5
Macaque
adhesion G protein-coupled receptor F5
Mouse
Rat
Dog
adhesion G protein-coupled receptor F5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IZF2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Surfactant metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Surfactant metabolism
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
GDB
Protein-Protein Interactions (30)
1 – 10 of 30
SFTPC
Tbio
Novelty: 0.00154396
Score: 0.92
Data Source: STRINGDB
SFTPB
Tbio
Novelty: 0.00163925
Score: 0.917
Data Source: STRINGDB
ARAP3
Tbio
Novelty: 0.05990082
Score: 0.721
Data Source: STRINGDB
NEBL
Tbio
Novelty: 0.02155964
Score: 0.659
Data Source: STRINGDB
ADGRA1
Tdark
Family: GPCR
Novelty: 0.24926468
Score: 0.646
Data Source: STRINGDB
FGD5
Tbio
Novelty: 0.03189653
Score: 0.622
Data Source: STRINGDB
ADCY4
Tbio
Family: Enzyme
Novelty: 0.00465974
Score: 0.61
Data Source: STRINGDB
MS4A7
Tdark
Novelty: 1.1093531
Score: 0.538
Data Source: STRINGDB
SSTR4
Tclin
Family: GPCR
Novelty: 0.01528237
Score: 0.538
Data Source: STRINGDB
PTGER1
Tclin
Family: GPCR
Novelty: 0.0013716
Score: 0.536
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.69

PubMed score by year
PubTator Score  3.57

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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