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Tbio
DOCK3
Dedicator of cytokinesis protein 3

Protein Summary
Description
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homolog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266037
  • ENSP00000266037
  • ENSG00000088538

Symbol
  • KIAA0299
  • MOCA
  • PBP
  • MOCA
  • NEDIDHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
protein domain
0.92
histone modification site profile
0.7
microRNA
0.56
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.88   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.88   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (63)
1 – 10 of 63
ELMO1
Tbio
Novelty:  0.01598587
p_int:  0.999999971
p_ni:  1e-9
p_wrong:  2.8e-8
Score:  0.965
Data Source:  BioPlex,STRINGDB
ELMO3
Tbio
Novelty:  0.05985405
p_int:  0.999999964
p_ni:  3.6e-8
p_wrong:  1e-9
Score:  0.969
Data Source:  BioPlex,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.97
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.963
Data Source:  STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.934
Data Source:  Reactome,STRINGDB
BDNF
Tchem
Novelty:  0.00006891
Score:  0.918
Data Source:  Reactome,STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.83
Data Source:  STRINGDB
SLC9A9
Tbio
Family:  Transporter
Novelty:  0.0343856
Score:  0.811
Data Source:  STRINGDB
NEDD9
Tbio
Novelty:  0.00539079
Score:  0.775
Data Source:  STRINGDB
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
Score:  0.75
Data Source:  STRINGDB
Pathways (160)
Activated NTRK2 signals through FYN (R-HSA-9032500)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FYN
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
NTRK2 activates RAC1
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FYN
Factors involved in megakaryocyte development and platelet production
Hemostasis
NTRK2 activates RAC1
Signal Transduction
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
4
4
88
eosinophil count
2
3
3
84.3
heel bone mineral density
1
2
2
76.7
body height
2
1
2
69.2
self reported educational attainment
3
2
3
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
4
88
eosinophil count
3
84.3
heel bone mineral density
2
76.7
body height
2
69.2
self reported educational attainment
3
66.6
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 3
VGNC:1794
460402
Macaque
dedicator of cytokinesis 3
701151
Mouse
MGI:2429763
208869
Rat
RGD:1306677
315992
Dog
dedicator of cytokinesis 3
VGNC:40047
476610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 3
Macaque
dedicator of cytokinesis 3
Mouse
Rat
Dog
dedicator of cytokinesis 3
Publication Statistics
PubMed Score 44.88
PubMed score by year
PubTator Score 371.08
PubTator score by year