Tdark SLC22A15 Solute carrier family 22 member 15

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc22 Family Of Organic Cation And Anion Transporters / Orphan Or Poorly Characterized Slc22 Family Members / Solute Carrier Family 22 Member 15

Protein Summary

Description

Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q8IZD6
• A8MUR3
• Q6UXP5
• Q8TAL9
• Q9NSH5

Gene Name

• SLC22A15

Ensembl ID

• ENST00000369502
• ENSP00000358514
• ENSG00000163393
• ENST00000369503
• ENSP00000358515

Symbol

• FLIPT1
• FLIPT1
• PRO34686

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
histone modification site profile	0.69
microRNA	0.55
PubMedID	0.53
tissue sample	0.52

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 22 member 15	VGNC:6127	469426
Macaque	solute carrier family 22 member 15		710102
Mouse	solute carrier family 22 (organic anion/cation transporter), member 15	MGI:3607704	242126
Rat	solute carrier family 22, member 15	RGD:1311184	310732
Dog	solute carrier family 22 member 15	VGNC:46276	483136

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 22 member 15
Macaque	solute carrier family 22 member 15
Mouse	solute carrier family 22 (organic anion/cation transporter), member 15
Rat	solute carrier family 22, member 15
Dog	solute carrier family 22 member 15

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8IZD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)

Reactome (5)

Organic cation transport (R-HSA-549127)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Organic cation transport	10 targets	R-HSA-549127
Reactome	Organic cation/anion/zwitterion transport	15 targets	R-HSA-549132
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Organic cation transport	10 targets	R-HSA-549127
Organic cation/anion/zwitterion transport	15 targets	R-HSA-549132
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
transmembrane transporter activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

• See Interactions on String-DB

ANKRD13C

Tbio

Novelty:  1.5309683

p_int:  0.999986677

p_ni:  0.000008306

p_wrong:  0.000005017

Data Source:  BioPlex

VAPA

Tbio

Novelty:  0.00169209

p_int:  0.999977975

p_ni:  0.000022025

Data Source:  BioPlex

ERGIC2

Tbio

Novelty:  0.08610944

p_int:  0.999830799

p_ni:  0.000169199

p_wrong:  2e-9

Data Source:  BioPlex

GHDC

Tbio

Novelty:  0.08423152

p_int:  0.999747748

p_ni:  0.000252252

Data Source:  BioPlex

VAPB

Tbio

Novelty:  0.00542377

p_int:  0.999555254

p_ni:  0.000444746

Data Source:  BioPlex

ZFPL1

Tbio

Novelty:  0.1829181

p_int:  0.998274541

p_ni:  0.001648662

p_wrong:  0.000076798

Data Source:  BioPlex

DPY19L4

Tdark

Family:  Enzyme

Novelty:  0.99997412

p_int:  0.98139111

p_ni:  0.018182299

p_wrong:  0.000426591

Data Source:  BioPlex

GUF1

Tbio

Novelty:  0.00422028

p_int:  0.975108235

p_ni:  0.024167658

p_wrong:  0.000724107

Data Source:  BioPlex

LMBRD2

Tdark

Novelty:  0.60495132

p_int:  0.962234967

p_ni:  0.034331621

p_wrong:  0.003433413

Data Source:  BioPlex

CNNM1

Tdark

Novelty:  0.11053515

p_int:  0.96086658

p_ni:  0.039131745

p_wrong:  0.000001675

Data Source:  BioPlex

Publication Statistics

PubMed Score  4.21

PubMed score by year

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PubTator Score  1

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Membrane
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Reference proteome
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Transmembrane helix
Transport