Tdark SLC22A15 Solute carrier family 22 member 15

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc22 Family Of Organic Cation And Anion Transporters / Orphan Or Poorly Characterized Slc22 Family Members / Solute Carrier Family 22 Member 15

Protein Summary

Description

Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q8IZD6
• A8MUR3
• Q6UXP5
• Q8TAL9
• Q9NSH5

Gene Name

• SLC22A15

Ensembl ID

• ENST00000369502
• ENSP00000358514
• ENSG00000163393
• ENST00000369503
• ENSP00000358515

Symbol

• FLIPT1
• FLIPT1
• PRO34686

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
histone modification site profile	0.69
microRNA	0.55
PubMedID	0.53
tissue sample	0.52

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (5)

Reactome (5)

Organic cation transport (R-HSA-549127)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Organic cation transport	10 targets	R-HSA-549127
Reactome	Organic cation/anion/zwitterion transport	15 targets	R-HSA-549132
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Organic cation transport	10 targets	R-HSA-549127
Organic cation/anion/zwitterion transport	15 targets	R-HSA-549132
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
transmembrane transporter activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

• See Interactions on String-DB

ANKRD13C

Tbio

Novelty: 1.81818182

p_int: 0.999986677

p_ni: 0.000008306

p_wrong: 0.000005017

Data Source: BioPlex

VAPA

Tbio

Novelty: 0.0022428

p_int: 0.999977975

p_ni: 0.000022025

Data Source: BioPlex

ERGIC2

Tbio

Novelty: 0.12696493

p_int: 0.999830799

p_ni: 0.000169199

p_wrong: 2e-9

Data Source: BioPlex

GHDC

Tbio

Novelty: 0.14562067

p_int: 0.999747748

p_ni: 0.000252252

Data Source: BioPlex

VAPB

Tbio

Novelty: 0.00566042

p_int: 0.999555254

p_ni: 0.000444746

Data Source: BioPlex

ZFPL1

Tbio

Novelty: 0.06292606

p_int: 0.998274541

p_ni: 0.001648662

p_wrong: 0.000076798

Data Source: BioPlex

DPY19L4

Tdark

Family: Enzyme

Novelty: 4

p_int: 0.98139111

p_ni: 0.018182299

p_wrong: 0.000426591

Data Source: BioPlex

GUF1

Tbio

Novelty: 0.00666297

p_int: 0.975108235

p_ni: 0.024167658

p_wrong: 0.000724107

Data Source: BioPlex

LMBRD2

Tdark

Novelty: 3

p_int: 0.962234967

p_ni: 0.034331621

p_wrong: 0.003433413

Data Source: BioPlex

CNNM1

Tdark

Novelty: 0.16670044

p_int: 0.96086658

p_ni: 0.039131745

p_wrong: 0.000001675

Data Source: BioPlex

Publication Statistics

PubMed Score  1.27

PubMed score by year

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PubTator Score  1

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQSAGEDQ

1-70

AFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKK

70-140

VYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVG

140-210

IAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFS

210-280

LTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPS

280-350

YPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYI

350-420

YTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLL

420-490

ETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDADEETQMIK

490-547

MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDADEETQMIK

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Uniprot Keyword

Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport