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Tbio
KMT2E
Inactive histone-lysine N-methyltransferase 2E

Protein Summary
Description
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:2362965 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257745
  • ENSP00000257745
  • ENSG00000005483
  • ENST00000311117
  • ENSP00000312379
  • ENST00000334884
  • ENSP00000335398
  • ENST00000476671
  • ENSP00000417888

Symbol
  • MLL5
  • MLL5
  • NKp44L
  • HDCMC04P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
transcription factor binding site profile
0.92
small molecule perturbation
0.86
protein domain
0.85
transcription factor
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.87   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.87   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999999923
p_ni:  7.7e-8
p_wrong:  1e-9
Data Source:  BioPlex
SETD1B
Tbio
Family:  Epigenetic
Novelty:  0.03331663
Score:  0.99
Data Source:  STRINGDB
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
Score:  0.99
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.975
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.97
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.969
Data Source:  STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.954
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.952
Data Source:  STRINGDB
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.944
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
84.7
mathematical ability
4
2
4
77.2
cognitive function measurement
1
2
2
71.3
waist-hip ratio
1
1
1
68.6
vitamin D measurement
2
2
2
67.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
84.7
mathematical ability
4
77.2
cognitive function measurement
2
71.3
waist-hip ratio
1
68.6
vitamin D measurement
2
67.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 2E
VGNC:14034
463640
Mouse
MGI:1924825
69188
Dog
lysine methyltransferase 2E
VGNC:42492
475895
Horse
lysine methyltransferase 2E
VGNC:19494
100058928
Cow
lysine methyltransferase 2E
VGNC:30694
539121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 2E
Mouse
Dog
lysine methyltransferase 2E
Horse
lysine methyltransferase 2E
Cow
lysine methyltransferase 2E
Publication Statistics
PubMed Score 59.87
PubMed score by year
PubTator Score 30.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title