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Tbio
COL27A1
Collagen alpha-1(XXVII) chain

Protein Summary
Description
Plays a role during the calcification of cartilage and the transition of cartilage to bone. This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356083
  • ENSP00000348385
  • ENSG00000196739

Symbol
  • KIAA1870
  • STLS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
transcription factor binding site profile
0.79
PubMedID
0.76
histone modification site profile
0.66
cell line
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.2   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
COL16A1
Tbio
Novelty:  0.11147945
Score:  0.927
Data Source:  STRINGDB
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.926
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.925
Data Source:  STRINGDB
COL14A1
Tbio
Novelty:  0.01760399
Score:  0.925
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.925
Data Source:  STRINGDB
COL28A1
Tdark
Novelty:  0.95671561
Score:  0.924
Data Source:  STRINGDB
COL12A1
Tbio
Novelty:  0.0239421
Score:  0.924
Data Source:  STRINGDB
COL8A1
Tbio
Novelty:  0.02203574
Score:  0.924
Data Source:  STRINGDB
COL7A1
Tbio
Novelty:  0.00232977
Score:  0.924
Data Source:  STRINGDB
COL4A4
Tbio
Novelty:  0.00833684
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
4
3
3
23.7
97.7
aspartate aminotransferase measurement
3
2
2
15.1
93
sex hormone-binding globulin measurement
4
1
4
78.6
apolipoprotein A 1 measurement
2
2
2
75
testosterone measurement
4
2
5
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
3
23.7
97.7
aspartate aminotransferase measurement
2
15.1
93
sex hormone-binding globulin measurement
4
78.6
apolipoprotein A 1 measurement
2
75
testosterone measurement
5
72.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type XXVII alpha 1 chain
VGNC:53281
464681
Mouse
MGI:2672118
373864
Rat
RGD:735115
298101
Anole lizard
collagen type XXVII alpha 1 chain
100567285
Zebrafish
ZDB-GENE-100119-1
100004688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type XXVII alpha 1 chain
Mouse
Rat
Anole lizard
collagen type XXVII alpha 1 chain
Zebrafish
Publication Statistics
PubMed Score 29.20
PubMed score by year
PubTator Score 9.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title