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Tbio
KIAA0319L
Dyslexia-associated protein KIAA0319-like protein

Protein Summary
Description
Possible role in axon guidance through interaction with RTN4R. (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. This gene is a candidate gene for dyslexia susceptibility.[provided by RefSeq, Apr 2009]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.8
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.1   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.1   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
54.7
1
1
0
1.5
54.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
54.7
0
1.5
54.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (63)
1 – 10 of 63
PI15
Tbio
Family: Enzyme
Novelty: 0.02244161
p_int: 0.999987866
p_ni: 0.000012134
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.99918295
p_ni: 0.00081705
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999139663
p_ni: 0.000860337
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.998452034
p_ni: 0.001547906
p_wrong: 5.9e-8
Data Source: BioPlex
FCN1
Tbio
Novelty: 0.01037775
p_int: 0.996159912
p_ni: 0.003840083
p_wrong: 5e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
CD4
Tclin
Novelty: 0.00001217
p_int: 0.993327496
p_ni: 0.006655012
p_wrong: 0.000017492
Data Source: BioPlex
PILRA
Tbio
Novelty: 0.05154386
p_int: 0.988610907
p_ni: 0.011389073
p_wrong: 2e-8
Score: 0.181
Data Source: BioPlex,STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
p_int: 0.987779016
p_ni: 0.012220969
p_wrong: 1.5e-8
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.984520878
p_ni: 0.013636325
p_wrong: 0.001842797
Data Source: BioPlex
MGAT4C
Tdark
Family: Enzyme
Novelty: 0.19680806
p_int: 0.982051113
p_ni: 0.017936308
p_wrong: 0.000012579
Data Source: BioPlex
Publication Statistics
PubMed Score  40.10

PubMed score by year
PubTator Score  9.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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