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Tbio
KIAA0319L
Dyslexia-associated protein KIAA0319-like protein

Protein Summary
Description
Possible role in axon guidance through interaction with RTN4R. (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. This gene is a candidate gene for dyslexia susceptibility.[provided by RefSeq, Apr 2009]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.8
cell type or tissue
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
p_int:  0.999987866
p_ni:  0.000012134
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.99918295
p_ni:  0.00081705
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999139663
p_ni:  0.000860337
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.998452034
p_ni:  0.001547906
p_wrong:  5.9e-8
Data Source:  BioPlex
FCN1
Tbio
Novelty:  0.01037775
p_int:  0.996159912
p_ni:  0.003840083
p_wrong:  5e-9
Score:  0.184
Data Source:  BioPlex,STRINGDB
CD4
Tclin
Novelty:  0.00001217
p_int:  0.993327496
p_ni:  0.006655012
p_wrong:  0.000017492
Data Source:  BioPlex
PILRA
Tbio
Novelty:  0.05154386
p_int:  0.988610907
p_ni:  0.011389073
p_wrong:  2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.987779016
p_ni:  0.012220969
p_wrong:  1.5e-8
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.984520878
p_ni:  0.013636325
p_wrong:  0.001842797
Data Source:  BioPlex
MGAT4C
Tbio
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.982051113
p_ni:  0.017936308
p_wrong:  0.000012579
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
64.4
1
1
0
1.5
64.4
sex hormone-binding globulin measurement
1
1
1
30.9
mean reticulocyte volume
1
1
1
21.6
BMI-adjusted waist circumference
2
1
2
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
64.4
0
1.5
64.4
sex hormone-binding globulin measurement
1
30.9
mean reticulocyte volume
1
21.6
BMI-adjusted waist circumference
2
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIAA0319 like
VGNC:6894
456742
Macaque
KIAA0319 like
712871
Mouse
MGI:2140475
100317
Rat
RGD:2306719
100294508
Dog
KIAA0319 like
VGNC:42344
482483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIAA0319 like
Macaque
KIAA0319 like
Mouse
Rat
Dog
KIAA0319 like
Publication Statistics
PubMed Score 58.37
PubMed score by year
PubTator Score 9.62
PubTator score by year
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Related Publications
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PMID
Year
Title