Tbio KIAA0319L Dyslexia-associated protein KIAA0319-like protein

Protein Summary

Description

Possible role in axon guidance through interaction with RTN4R. (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. This gene is a candidate gene for dyslexia susceptibility.[provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• Q8IZA0
• B1AN13
• D3DPR8
• O95010
• Q6PJJ7
• Q7L1C9
• Q8N2B3
• Q8NDA0
• Q8WY39
• Q8WYZ5
• Q96IC3
• Q96JJ0
• Q9BUW6
• Q9H7V0

Gene Name

• KIAA0319L

Ensembl ID

• ENST00000325722
• ENSP00000318406
• ENSG00000142687

Symbol

• AAVR
• KIAA1837
• AAVR
• AAVRL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.93
kinase perturbation	0.88
protein domain	0.85
transcription factor binding site profile	0.8
cell type or tissue	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.37   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.37   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0