Tbio TRMT2A tRNA (uracil-5-)-methyltransferase homolog A

Protein Summary

Description

May be involved in nucleic acid metabolism and/or modifications. The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q8IZ69
• D3DX25
• Q32P57
• Q96ME6
• Q9H732

Gene Name

• TRMT2A

Ensembl ID

• ENST00000252136
• ENSP00000252136
• ENSG00000099899
• ENST00000403707
• ENSP00000385807
• ENST00000404751
• ENSP00000384968

Symbol

• HTF9C
• HTF9C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
interacting protein	0.78
histone modification site profile	0.77
transcription factor	0.71
small molecule perturbation	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.23   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.23   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0