Tbio CHPF Chondroitin sulfate synthase 2

Protein Summary

Description

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.

Uniprot Accession IDs

• Q8IZ52
• B4DXU0
• Q6UXD6
• Q7L4G1
• Q9H0F8
• Q9H618

Gene Name

• CHPF

Ensembl ID

• ENST00000243776
• ENSP00000243776
• ENSG00000123989
• ENST00000535926
• ENSP00000445571

Symbol

• CSS2
• CSS2
• CHSY2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
transcription factor binding site profile	0.76
cellular component	0.73
pathway	0.68
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Chondroitin Sulfate Synthase 2

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Chondroitin Sulfate Synthase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.28   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.28   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0