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Tbio
CHPF
Chondroitin sulfate synthase 2

Protein Summary
Description
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243776
  • ENSP00000243776
  • ENSG00000123989
  • ENST00000535926
  • ENSP00000445571

Symbol
  • CSS2
  • CSS2
  • CHSY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor binding site profile
0.76
cellular component
0.73
pathway
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
CSGALNACT1
Tbio
Family:  Enzyme
Novelty:  0.03463325
Score:  0.953
Data Source:  STRINGDB
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
Score:  0.953
Data Source:  STRINGDB
BCAN
Tbio
Novelty:  0.00737982
Score:  0.951
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.95
Data Source:  STRINGDB
DCN
Tbio
Novelty:  0.00073027
Score:  0.932
Data Source:  STRINGDB
CSPG4
Tbio
Novelty:  0.0038499
Score:  0.931
Data Source:  STRINGDB
BGN
Tbio
Novelty:  0.00139486
Score:  0.931
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.927
Data Source:  STRINGDB
CHSY1
Tbio
Family:  Enzyme
Novelty:  0.03515909
Score:  0.916
Data Source:  STRINGDB
CHSY3
Tdark
Family:  Enzyme
Novelty:  0.17103933
Score:  0.911
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
88.8
creatinine measurement
1
2
2
85.6
electrocardiography
1
1
60
68.6
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
53.3
vital capacity
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
88.8
creatinine measurement
2
85.6
electrocardiography
60
68.6
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
53.3
vital capacity
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chondroitin polymerizing factor
VGNC:135
743513
Macaque
chondroitin polymerizing factor
703860
Mouse
MGI:106576
74241
Rat
RGD:1359458
316533
Horse
chondroitin polymerizing factor
VGNC:16515
100059511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chondroitin polymerizing factor
Macaque
chondroitin polymerizing factor
Mouse
Rat
Horse
chondroitin polymerizing factor
Publication Statistics
PubMed Score 37.00
PubMed score by year
PubTator Score 13.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title