Tbio RASEF Ras and EF-hand domain-containing protein

Protein Summary

Description

Binds predominantly GDP, and also GTP. This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q8IZ41
• A6NC29
• Q96N04

Gene Name

• RASEF

Ensembl ID

• ENST00000340717
• ENSP00000345651
• ENSG00000165105
• ENST00000376447
• ENSP00000365630

Symbol

• RAB45
• RAB45

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
protein domain	0.92
gene perturbation	0.81
tissue sample	0.6
cell type or tissue	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0