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Tbio
GPR135
G-protein coupled receptor 135

Protein Summary
Description
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395116
  • ENSP00000378548
  • ENSG00000181619
  • ENST00000481661
  • ENSP00000432696

Symbol
  • HUMNPIIY20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
cell type or tissue
0.58
tissue sample
0.56
cell line
0.53
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (39)
1 – 10 of 39
PTAFR
Tchem
Family: GPCR
Novelty: 0.00890235
Score: 0.716
Data Source: STRINGDB
GPR141
Tdark
Family: GPCR
Novelty: 0.28510819
Score: 0.668
Data Source: STRINGDB
GPR62
Tbio
Family: GPCR
Novelty: 0.58385933
Score: 0.64
Data Source: STRINGDB
GPR142
Tchem
Family: GPCR
Novelty: 0.09709117
Score: 0.639
Data Source: STRINGDB
TIMM9
Tbio
Family: Enzyme
Novelty: 0.04531878
Score: 0.629
Data Source: STRINGDB
GPR25
Tdark
Family: GPCR
Novelty: 0.79342387
Score: 0.628
Data Source: STRINGDB
FBXO34
Tdark
Score: 0.628
Data Source: STRINGDB
GPR162
Tbio
Family: GPCR
Novelty: 0.1214531
Score: 0.609
Data Source: STRINGDB
OR6V1
Tdark
Family: oGPCR
Novelty: 6
Score: 0.57
Data Source: STRINGDB
PSMA3
Tbio
Family: Enzyme
Novelty: 0.0516045
Score: 0.569
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.51

PubMed score by year
PubTator Score  2.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer