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Tbio
ANKRD13A
Ankyrin repeat domain-containing protein 13A

Protein Summary
Description
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261739
  • ENSP00000261739
  • ENSG00000076513

Symbol
  • ANKRD13
  • ANKRD13
  • NY-REN-25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor binding site profile
0.86
kinase perturbation
0.81
cell type or tissue
0.68
histone modification site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
35
intelligence
1
1
1
24.5
cognitive function measurement
1
1
1
17.8
hematocrit
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
35
intelligence
1
24.5
cognitive function measurement
1
17.8
hematocrit
1
10.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 13A
VGNC:4922
452228
Macaque
ankyrin repeat domain 13A
708383
Mouse
MGI:1915670
68420
Rat
RGD:1308577
360823
Dog
ankyrin repeat domain 13A
VGNC:37884
609384
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 13A
Macaque
ankyrin repeat domain 13A
Mouse
Rat
Dog
ankyrin repeat domain 13A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IZ07-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (49)
1 – 10 of 49
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.999926778
p_ni:  0.000003364
p_wrong:  0.000069858
Data Source:  BioPlex
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.998672649
p_ni:  0.001327351
Data Source:  BioPlex
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.996200757
p_ni:  0.003799243
Score:  0.22
Data Source:  BioPlex,STRINGDB
UBTD1
Tdark
Novelty:  0.50393104
p_int:  0.992389388
p_ni:  0.007610612
Data Source:  BioPlex
RALB
Tbio
Family:  Enzyme
Novelty:  0.01605746
p_int:  0.980876743
p_ni:  0.019123257
Data Source:  BioPlex
FAM153B
Tdark
Novelty:  4.34922003
p_int:  0.979155279
p_ni:  0.020844721
Score:  0.161
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.977323045
p_ni:  0.022676954
Data Source:  BioPlex
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.976629433
p_ni:  0.023370566
p_wrong:  1e-9
Data Source:  BioPlex
IZUMO1
Tbio
Novelty:  0.01839953
p_int:  0.963857244
p_ni:  0.036142756
Data Source:  BioPlex
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
p_int:  0.962380267
p_ni:  0.030586147
p_wrong:  0.007033587
Data Source:  BioPlex
Publication Statistics
PubMed Score  3.07

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer