Tbio LRRC34 Leucine-rich repeat-containing protein 34

Protein Summary

Description

Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.

Uniprot Accession IDs

• Q8IZ02
• B4DEJ7
• E9PBH2
• G5E9T7

Gene Name

• LRRC34

Ensembl ID

• ENST00000446859
• ENSP00000414635
• ENSG00000171757
• ENST00000522526
• ENSP00000429278

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78
PubMedID	0.64
gene perturbation	0.57
tissue sample	0.55
transcription factor binding site profile	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.6   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.6   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0