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Tdark
TBC1D21
TBC1 domain family member 21

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300504
  • ENSP00000300504
  • ENSG00000167139
  • ENST00000535547
  • ENSP00000439325

Symbol
  • MgcRabGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
cell type or tissue
0.78
cellular component
0.65
molecular function
0.56
disease perturbation
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
5
0
9.9
99.1
BMI-adjusted waist circumference
7
8
23
89
body fat distribution
3
1
5
77.6
BMI-adjusted hip circumference
2
5
5
76.5
body height
2
2
2
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
9.9
99.1
BMI-adjusted waist circumference
23
89
body fat distribution
5
77.6
BMI-adjusted hip circumference
5
76.5
body height
2
71.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 21
VGNC:3524
748837
Macaque
TBC1 domain family member 21
700124
Mouse
MGI:1921536
74286
Rat
RGD:1310243
363072
Dog
TBC1 domain family member 21
VGNC:47140
611467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 21
Macaque
TBC1 domain family member 21
Mouse
Rat
Dog
TBC1 domain family member 21
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IYX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (54)
1 – 10 of 54
CCNDBP1
Tbio
Novelty:  0.01527762
p_int:  0.999997958
p_ni:  0.000002042
Data Source:  BioPlex
CATIP
Tdark
Novelty:  0.28211918
Score:  0.814
Data Source:  STRINGDB
FN3K
Tbio
Family:  Kinase
Novelty:  0.02600747
Score:  0.773
Data Source:  STRINGDB
CIZ1
Tbio
Novelty:  0.03730538
Score:  0.748
Data Source:  STRINGDB
NANP
Tbio
Family:  Enzyme
Novelty:  0.01876342
Score:  0.717
Data Source:  STRINGDB
TSSK4
Tbio
Family:  Kinase
Novelty:  0.14893178
Score:  0.712
Data Source:  STRINGDB
GPSM2
Tbio
Novelty:  0.00941766
Score:  0.693
Data Source:  STRINGDB
HSPB6
Tbio
Novelty:  0.00317712
Score:  0.691
Data Source:  STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
Score:  0.658
Data Source:  STRINGDB
ZNF846
Tdark
Family:  TF
Novelty:  16.95192195
Score:  0.656
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.33

PubMed score by year
PubTator Score  1.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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